Evaluation of Oxidative Stress and Antioxidant Status in Patients with Type 2 Diabetes Mellitus and its Correlation with Glycosylated Hemoglobin
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 1
Abstract
Aim: To evaluate serum Total Antioxidant Capacity(TAC) and serum Total Peroxidase (TP) Oxidative Stress Index (OSI) and measure its correlation with Glycosylated Hemoglobin (GHM). Study design: an analytical case control study. Place and Duration of study: Department of Biochemistry, School of health and allied science, Pokhara University, between November 2012 and February 2013. Methodology: The study encompassed of 110 subjects who were distributed into two groups, 55 Type 2 Diabetic Mellitus (T2DM) and 55 healthy controls, relying on serum Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS) clinical history and medication. Serum values of TAC and TP were measured; OSI was calculated and correlated with GHM. Biochemical markers (serum urea, creatinine, protein, albumin and bilirubin) were also determined in all study subjects. Results: The results showed non-significant differences in two groups with respect to age, body mass index and blood pressure (all p>0.05).Serum level of FBS, PPBS, GHB and MBG (mean blood glucose) were significantly higher in T2DM subjects (p > 0.05). Spearman’s correlation analysis in the T2DM subjects showed a statistical significant and positive correlation of FBS with OSI, PPBS with TP and GHB with OSI, TP but negative correlation of GHB with TAC and that of TP and OSI with total protein and total bilirubin while non-significant correlation with urea, and creatinine. Conclusion:T2DM subjects showed higher level of TP and OSI index and lower level of TAC with regard of decreased individual antioxidant - total protein, albumin, uric acid and total bilirubin.
Authors and Affiliations
Niraj Chaudhary,Nidhi Sharma Chapagain,Rabindra Kumar Baral,Sanjog Timilsina,Surendra Tiwari
Keywords
Related Articles
- EP ID EP39838
- DOI -
- Views 319
- Downloads 0
Morbidity Pattern among Urban Slum Women beyond Reproductive Years
Background: With changing demographic profile India has older women than men as life expectancy for women is 67.57 as against 65.46 for men. Both social and health needs of the older women are unique and distinctive as...
THE BIRTH OF A NEW JOURNAL
Abstract:On behalf of all members of the editorial board, we welcome you to our new online journal, International Journal of Medical and Health Sciences. In this era of explosive growth of knowledge and publishing, we ha...
Dermatoglyphics: An Economical Tool for Prediction of Diabetes Mellitus
Diabetes Mellitus being one of the curse of human civilization is said to be genetically linked. Dermatoglyphics of the individual are also genetically determined and remains constant throughout the life. In the presen...
Psychosocial Predictors Of Coronary Risk Factors Among Employees In A Government Organisation
Introduction: The link between body and mind is a very powerful one.Coronary artery disease (CAD) is no exception. Research has linked several risk factors to cardiovascular disease which can be categorized as physiolo...
Zika Virus Disease: A re-emerging disease with pandemic potential
Emerging and reemerging disease are increasing in the recent past posing great threat to the human population. Re-emerging communicable diseases are those which are known and reappear after a decline in incidence. The Z...