Evaluation of oxidative stress and lipid profile in patients of generalized vitiligo

Journal Title: International Journal of Medical Science and Public Health - Year 2016, Vol 5, Issue 3

Abstract

Background: Restricted depigmented macules that lack melanocytes signify vitiligo. Complicated genetic, immunological, neural, and self-destructive mechanisms are involved in its pathogenesis. It has been proposed that oxidative stress is the primary pathogenic event according to autocytotoxic hypothesis. Objective: To study the antioxidant defenses in patients of generalized vitiligo. Materials and Methods: A total of 120 subjects were enrolled for the study; of which sixty were patients with generalized vitiligo and sixty were age- and sex-matched healthy controls. All the subjects were evaluated for the lipid profile and erythrocyte antioxidant enzyme activities such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxi - dase (GPx). Result: The low-density lipoprotein(LDL) and very low-density lipoprotein(VLDL) cholesterol levels were found to be signif- icantly higher ( p < 0.001) in vitiligo patients. The activities of CAT and GPx were significantly higher ( p < 0.001), whereas there was no significant difference observed in SOD activity in vitiligo patients. Conclusion: There are depleted activities of the antioxidant enzymes CAT and GPx in generalized vitiligo, suggesting a high oxidative stress. Thus, a proper antioxidant therapy should be incorporated as an adjuvant in the management of vitiligo

Authors and Affiliations

Arun Kumar Metta, Sandhya Metta, Imran Kazmi, Govind Raj

Keywords

Related Articles

An epidemiological study to assess the risk factors and complications among patients with diabetes: A community-based study in Ahmedabad

Background: Diabetes mellitus (DM) is a chronic metabolic disease. The prevalence of diabetes is reaching epidemic levels worldwide, more so in developing countries like India due to rapid urbanization. Type 2 DM is a pr...

Enuresis improvement and its associated factors among children attending enuresis clinic at Rusaifah

Background: Enuresis is a common non-lethal health problem, causing a great deal of stress, confusion, and frustration to the suffering children, parents, and physicians. Objectives: Finding and evaluating the sco...

Correlation of body mass index, dietary habits, and family history with hypertension in adolescents

Background : The prevalence of hypertension has significantly increased among adolescents in India. Objective: (1) To correlate the hypertension with body mass index (BMI), dietary habits, and family history of hyper...

Knowledge and practice regarding contraception and population control among higher secondary school students in Ahmedabad

Background: In India, adolescent pregnancies are very common because of early marriages, lack of knowledge of contraception, and increase in sexual activity among adolescents, together leading to early child bearing in...

Effectiveness of visual auditory kinesthetic tactile technique on reading level among children with dyslexia at Helikx Open School and Learning Centre, Salem

Background: Each and every child is special, born with a unique talent to explore this world. The word dyslexia is derived from the Greek language in which dys means “poor” or “inadequate” and lexis means...

Download PDF file
  • EP ID EP90550
  • DOI 10.5455/ijmsph.2016.1008201590
  • Views 150
  • Downloads 0

How To Cite

Arun Kumar Metta, Sandhya Metta, Imran Kazmi, Govind Raj (2016). Evaluation of oxidative stress and lipid profile in patients of generalized vitiligo. International Journal of Medical Science and Public Health, 5(3), 493-496. https://europub.co.uk/articles/-A-90550