Evaluation of pancytopenia in adults through haematological parameters and bone marrow studies
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction Pancytopenia simultaneous presence of anemia leucopenia and thrombocytopenia is a common clinical entity that we see in day to day practice Proper diagnostic evaluation requires detailed clinical history physical examination and haematological assessment including careful peripheral blood smear examination and bone marrow evaluationMaterials and Methods A total of 80 adult patients with pancytopeniabicytopenia presenting between January 2016 to January 2017 were included in the study All patients underwent detailed clinical history and physical examination Careful peripheral blood smear examination CBC and bone marrow aspirate was done in all Bone marrow biopsy was done wherever feasibleResults Megaloblastic anemia was the commonest cause of pancytopeniabicytopenia making up 375 of all cases followed by erythroid hyperplasia 20 aplastic anemia 10 Haematological malignancies accounted for 2375 cases of the total Bone marrow biopsy aided in the diagnosis of 8 cases 6 cases of aplastic anemia and two cases of dry tap while in others it was concordant with aspiration findingsConclusion Bone marrow aspiration and biopsy are an important adjunct to peripheral smear examination for evaluation of cytopenias Bone marrow trephine biopsy is helpful in cases of dry tap We also conclude that there is high prevalence of megaloblastic anemia due to nutritional deficiency among young population Hence this age range should be the prime target for education regarding proper dietary habits the remediation of which might reduce the clinical burden of megaloblastic anemiaKeywords Bone marrow aspiration Megaloblastic anemia Pancytopenia
Authors and Affiliations
Prashant Prakash, Pooja Agarwal, Asbah Shams, Harendra Kumar, Ashwini Nigam
Keywords
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- EP ID EP475911
- DOI 10.18231/2394-6792.2018.0106
- Views 53
- Downloads 0
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