Evaluation of Pap Smear And HPV VLP Serology in Clinically Suspected Cases Of Cervical Cancer in Perimenopausal Women in A Tertiary Care Centrein Kolkata
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Context:Carcinoma cervix is the most common genital tract carcinoma encountered among females in clinical practice in India. Pap smear is the most commonly used screening tool for early detection of cervical carcinoma. Also HPV (Human papilloma virus)VLP (Virus like particles) serology may act as an adjunctive screening procedure. Aims and Objectives:1)To evaluate the cytological findings in clinically suspected cases of cervical cancer in perimenopausal women by conventional pap smear and correlate with biopsy findings; 2)To determine the HPV serological status and its role as a screening procedure. Materials and Methods:Ninetyperimenopausal women, clinically suspected of having cervical carcinoma, were chosen over a one year period. They were clinically examined, relevant history taken,cytologically evaluated. All such cases were corroborated with their respective histological interpretation and were serologically evaluated for HPV VLP antibodies by ELISA (Enzyme linked immunosorbent assay).Statistical analysis:Sensitivity, specificity, accuracy, positive predictive value and negative predictive value of Pap smear were calculated, taking histopathology as the gold standard. Kappa value was determined using SPSS 18 version. Results:Overall sensitivity, specificity, positive predictive value, negative predictive value and accuracy of conventional cytology with respect to histopathology were 78.13%,96.3%,92.6%,88.14%,89.5%respectively ( k = 0.456). Only one case, with cervical intraepithelial neoplasia 2 (CIN2), was serologically positive for anti- HPV antibodies. Conclusion:Pap smear had moderate agreement with cervical histology in this study. However HPV VLP serology could not be established as a screening test for cervical carcinoma in perimenopausal women. Keywords:Cervical cancer, HPV VLP Serology,PAP smear,Perimenopausal women. Keymessages: Pap smear is a cost-effective screening tool with high accuracy for premalignant and malignant lesions of cervix. HPV VLP serology could not be established as a screening tool in perimenopausal women in cervical cancer.
Authors and Affiliations
Raisa Ghosh, Sumit Nandy, Sukla Naskar, Baishakhi Paria, Prof. Keya Basu, Prof. Arati Biswas
Keywords
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- EP ID EP596031
- DOI 10.9790/0853-1603064449
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