Evaluation of Pap Smears of Cases with Significant Endometrial Histopathology for the Presence and Morphology of Endometrial Cells
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 1
Abstract
Background: Endometrial cells are rarely seen in pap smears. Their presence in postmenopausal women > 45 years may suggest endometrial pathology. Aims: To evaluate the pap smears of cases with significant endometrial histopathology for the presence of endometrial cells; its association with age and menopausal status and its sensitivity in detection of endometrial pathology. Settings & Design: Cross sectional retrospective case control study. Meterials and Methods: Endometrial biopsies grouped as cases (significant endometrial pathology hyperplasia, carcinoma, polyps, carcinoma) and control (basal, proliferative, secretory) were collected for a period of two years. Their pap smears were evaluated for the presence of endometrial cells. Statistical Analysis: Descriptive statistics was used. Results: Among the 58 cases and 58 controls, endometrial cells were present in 31% (18/58) of cases and 17% (10/58) of controls. Age >45 years, menopausal status and postmenopausal bleeding had no association. 25% of simple hyperplasia, 50% of complex hyperplasia, 37.5% of endometrial polyp and 50% of endometrial carcinoma cases had endometrial cells. The sensitivity of detection of significant endometrial pathology by endometrial cells was 31%; specificity 82%; positive predictive value 64% and negative predictive value 54%. The average number of clusters were >2 in the cases and <2 in the control. The clusters had papillae/club like/swirl morphology or atypical in cases. Conclusion: We conclude from our study that we should document the presence of endometrial cells in patients with any symptom of irregular bleeding irrespective of age and menopausal status especially when there are more than two clusters with distinct morphologies like papillae/ club/swirls.
Authors and Affiliations
Sylvia Mary T
Keywords
Related Articles
- EP ID EP512127
- DOI 10.21088/ijprp.2278.148X.7118.10
- Views 84
- Downloads 0
Her-2/neu Revisited - The Role of Her2neu in Colorectal Carcinoma: A Three Year Study on Colonoscopic Biopsies
Introduction: Finding newer modalities of treatment is the need of the hour for Colorectal carcinoma as the incidence of is on the rise. One such is the finding of overexpression of “Her-2/neu” a biological marker, with...
Study on Quick Score of Hormone Receptor Status of Breast Carcinoma
Introduction: Breast acer is a common cancer in Indian population. The assessment of estrogen receptor (ER) status of breast carcinoma is a routine practice to predict the likely outcome of endocrine therapy. The assessm...
Fine Needle Aspiration Cytology of Palpable Breast Lump: A Study of 2 Years
Obective: Breast lumps constitute a significant proportion of surgical cases in women of both developed and developing countries. It is needed to distinguish benign lumps from malignant preoperatively for definite treatm...
Cytomorphological Study of Cervical Lymph Node Lesions: A Study of 173 Cases
Introduction: Cervical lymph node enlargement is frequent presentation in all age groups with a wide spectrum of diseases, ranging from infections to malignancy. Therefore, management of cases depends on lymph node patho...
Diagnostic Efficacy of Cell Block Technique as a Complementary Adjunct to Fine Needle Aspiration CytologyDiagnostic Efficacy of Cell Block Technique as a Complementary Adjunct to Fine Needle Aspiration Cytology
Background: Though fine needle aspiration cytology is the most routinely performed and widely accepted diagnostic procedure for an initial diagnosis in any swelling, we often come across difficulties in diagnosis, if the...