Evaluation of Patients with Paracetamol Intoxication Who Admitted to Emergency Service
Journal Title: Meandros Medical and Dental Journal - Year 2016, Vol 17, Issue 1
Abstract
Objective: To evaluate the effects of demographic and clinical features on follow-up period and laboratory parameters in patients with paracetamol intoxication who were admitted to our emergency department. Materials and Methods: One hundred sixty-four patients, who were admitted to the emergency department at Adnan Menderes University Faculty of Medicine between April 2013 and April 2015, were retrospectively evaluated and a total of 44 patients who have ingested paracetamol were enrolled in the study. The demographic and laboratory data of the patients were recorded. The study protocol was approved by the Ethics Committee and Institutional Review Board of Adnan Menderes University Faculty of Medicine. Results: Of the 44 patients, 29 were followed up in the observation unit at the emergency department (OUED), while 15 were followed up in the critical care unit at the emergency department (CCUED). There was no difference in age, sex and additional drug usage between the groups. Paracetamol dose was significantly higher in CCUED group than in OUED group (15013±6942 vs. 5351±3382 mg, p<0.001). Antidote administration was performed in 14 patients in CCUED (93.3%) and 12 patients in OUED groups (41.1%) (p=0.003). When we compared the patients who received antidote treatment with those who did not, it was observed that the dose of paracetamol (12344±6388 vs. 3302±1291 mg, p<0.001) and the length of hospitalization (2.46±0.7 vs. 1.39±0.6 day, p<0.001) were significantly higher in antidote-administered patients. The international normalized ratio (INR) was also significantly higher in patients who received antidote treatment than in those who did not receive (1.14±0.14 vs. 1.05±0.13, p=0.042). Conclusion: The role of emergency physicians in triage is very important. Laboratory findings are not important in the management of paracetamol intoxication in patients admitted to the emergency department. Intravenous administration of N-acetylcysteine as antidote has a lowering effect on INR in patients with paracetamol poisoning.
Authors and Affiliations
Kıvanç Karaman, Mücahit Avcil, Burçak Kantekin, Yunus Emre Özlüer, Hüseyin Emre Yaşar, Sibelnur Avcil
Keywords
Related Articles
- EP ID EP235924
- DOI 10.4274/meandros.2533
- Views 106
- Downloads 0
Comparison of the Load-bearing Capacities of Monolithic PEEK, Zirconia and Hybrid Ceramic Molar Crowns
Objective: Although polyether ether ketone (PEEK) shows high biocompatibility in prosthetic dentistry, there is inadequate information about its clinical applications and limits. The purpose of this study was to compare...
A Newborn with Dandy-Walker Malformation and Aortic Coarctation
Dandy-Walker malformation (DWM) is a rare anomaly of the posterior cranial fossa. Concomitant brain or systemic malformations are frequent and can influence the prognosis. DWM is associated with cardiac abnormalities. Re...
Color Stability of NeoMTA Plus and MTA Plus when Mixed with Anti-washout Gel or Distilled Water
Objective: This study aims to evaluate the effect of the special anti-washout gel mixing agent on the color stability of mineral trioxide aggregate (MTA) Plus and NeoMTA Plus in contact with distilled water, ethylenediam...
Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis
Objective: The aim of the study was to determine the influence of initial periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases. Materials...
Vitamin D Level and Infertility
Infertility is one of the major health problems of our time. In fact, infertility is caused by many factors. Among these factors the effect of vitamin D levels of infertility are overlooked. The prevalence of vitamin D d...