EVALUATION OF PHARMACOLOGICAL PROFILE OF KOJU®- A NIGERIAN POLYHERBAL FORMULATION, IN WISTAR RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
Polyherbal formulations are mixtures of many plant parts obtained from various plant species and families. These plant combinations usually contain a wide array of bioactive compounds making them suitable for the treatment and management of a variety of disease conditions. These formulations are prepared most often and dispensed by individuals without formal training. As a result, experimental screening method is important in order to ascertain the efficacy and safety of these herbal products. This study investigated the pharmacological profile of Koju® (KPF) - a common Nigerian polyherbal formulation developed from Xylopia aethiopica (root bark), Securidaca longepedunculata (stem bark), Magnifera indica (stem bark), Allium sativum (seed), Citrus aurantifolia (root bark), Morinda lucida (seed) and Saccharum officinarum. The pharmacological profile was evaluated via investigation of its anti-hyperglycaemic potential (using alloxan- induced diabetes rat model), anti- bacterial potential (using in vitro action against bacterial isolates), anti- malarial potential (using P. berghei berghei inoculated mice model), analgesic potentials (using hot plate method), anti- inflammatory potential (using egg albumin- induced paw oedema model) and anti- pyretic (using bakers’ yeast induced hyperpyrexia model). Results showed that KPF reduced hyperglycaemia in rats, Inhibited salmonella spp isolate in vitro and P. berghei berghei in mice and exhibited analgesic and inflammatory effect in rats. It was concluded that anti-hyperglycaemic, anti- bacterial, anti- malarial, analgesic and anti- inflammatory activities are part of the pharmacological profile of Koju polyherbal formulation.
Authors and Affiliations
Idakwoji Precious Adejoh
Keywords
Related Articles
- EP ID EP618978
- DOI -
- Views 103
- Downloads 0
EVALUATION OF THE ANTIMICROBIAL EFFECT OF EXPIRED ORAL ANTIBIOTICS IN-VITRO.
Background: In spite of significant risks, as well as non-clinical importance due to loss of potency, stiff penalties against administration of expired antibiotics are still not appropriately enforced by health policy ma...
HAASE ENZYME AS INDICTER FOR DIAGNOSING THE RHEUMATOID ARTHRITIS (RA) DISEASE FOR HUMAN
In this study, the activity of (HAase) enzyme for (30) serum samples of patients suffering from (RA) were experimentally investigated. Serum samples are gathered from women suffering from RA disease at age range from 20-...
ROLE OF LAGHUMALINIVASANT RASA IN UPVISHTAK (INTRA UTERINE GROWTH RETARDATION)
Intra uterine growth restriction (IUGR) refers to a condition in which a foetus is unable to achieve its genetically determined potential size. This functional definition seeks to identify a population of foetuses at ris...
A REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF VALGANCICLOVIR HYDROCHLORIDE
Many theories have proposed to explain the Analytical method development and validation of Valganciclovir hydrochloride. Although the literature survey covers a wide variety of such theories, so the development of sound...
LIQUID- LIQUID EXTRACTION METHOD FOR EXTRACTION ZN(II) FROM AQUEOUS SOLUTIONS BY ORGANIC REAGENT
Extraction experiments for Zn+2 ion from aqueous phase by new laboratory prepared Azo derivation as complexation agent 2- [(4- Benzyloxy phenyl)azo]- 5- nitro-4-phenyl imidazole (BANI) shows the optimum conditions for th...