Evaluation of Plasma Leptin in Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Background: Leptin is an adipokine that has been shown to be involved in pathways influencing the risk of cardiovascular disease and diabetes mellitus. Aims: To estimate and compare plasma leptin levels in type 2 diabetes mellitus (T2DM) patients with normal healthy individuals. Materials and methods: 60 T2DM patients and 50 age matched healthy individuals were taken as cases and controls respectively, in a case-control study conducted from October 2013 to September 2015 in the Department of Biochemistry in collaboration with the Department of Medicine, RIMS, Imphal. Fasting plasma leptin levels was estimated by DRG Leptin (Sandwich) ELISA kit manufactured by DRG Instruments GmbH, Germany Frauenberstrabe 18, D-35039 Maburg. Serum lipid profile estimation was done by enzymatic colorimetric test with lipid clearing factor (LCF) by kits marketed by Human Gesellschaft fur Biochemica and Diagnostica GmbH Germany. Results: The mean duration of diabetes in cases was 5.56±3.30 years. The mean value of leptin (ng/ml) was 9.91±5.62 in cases and 5.11±2.66 in controls. Out of 60 patients, 20 had high plasma leptin levels whereas, 40 had leptin levels within the normal range. Leptin was positively correlated with waist-hip ratio (r=0.626, p= 0.000), total cholesterol (r=0.39, p=0.002) and LDL-Cholesterol (r=0.315, p=0.014) and it was negatively correlated with HDL-Cholesterol (r= -0.293, p=0.023). Conclusion: Increased levels of plasma leptin is an important risk factor for developing diabetes.
Authors and Affiliations
Dr C Lalrindik, Dr Chanchal L Chanu, Dr L Shaini, Dr Balary Nongtdu, Dr Saishyam Sadanandam, Dr Wahengbam Diana Devi, Dr Ng Taruni Devi
Keywords
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- EP ID EP434788
- DOI 10.9790/0853-1801083135.
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