Evaluation of Portal Hypertension Doppler Parameters after Hepatitis C Virus Eradication in Patients with Definite Fibrosis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 11
Abstract
Backgrounds and aims: Eradication of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) nowadays is almost always successful and sustained virological response (SVR) occurs in more than 90% of cases and this prevent more fibrosis and preclude the progression of portal hypertension (PH). We aimed to evaluate the portal hypertensive Doppler parameters as a marker of PH after treatment of HCV with DAAs. Methods: 200 patients with post chronic HCV infection and definite liver fibrosis ≥F2 were included. All patients underwent laboratory investigations (liver function tests, complete blood count and serum creatinine), abdominal ultrasonography (US), portal Doppler US, fibroscan and upper endoscopy examinations. All patients were treated with DAAs for 12 weeks and then reevaluated for laboratory tests, fibroscan and hepatic Doppler US at the end of treatment and 6 months later. Comparison between those investigations at baseline, end of treatment and 6 months after treatment was analyzed.Results: 120 females (60%) and 80 males (40%) were included. Their mean ages were 45.0±12.9; and mean Child- Pugh score was 6.35±1.2. The mean baseline value for fibroscan was 16.17±3.9 kPa; thirteen of them (6.5%) were F2, 63 (31.5%) were F3 and 124 (62%) were F4. Liver function tests including serum bilirubin and albumin, prothrombin time and concentration (PT& PC), liver enzymes (ALT and AST) were improved with variable significant values 6 months after treatment. Also Hemoglobin and platelet count were significantly increased both at the end of treatment and 6 months later. Fibroscan values decreased significantly both at the end of treatment and 6 months later (P value= 0.001 and 0.000 respectively). Portal hypertensive parameters including portal vein velocity (PVV), portal volume flow (PVF), portal hypertensive index (PHI), congestion index of portal vein (CI) and Spleno-portal index (SPI) were improved significantly both at the end of treatment and 6 months later (P value= 0.001 and 0.000 respectively, for all parameters). Patients without esophageal varices (OVs) showed more significant degrees of improvement in both fibroscan and portal hypertensive parameters than those with varices. Conclusions: Doppler portal hypertensive parameters, as a marker of portal hypertension, were improved in parallel with the improvement in fibroscan values after viral clearance and its improvement in early conditions in the current study mandate urgent treatment to avoid possible complications.
Authors and Affiliations
Hasan Sedeek Mahmoud1 , Heba Ahmed Osman1 , Ghada Mohamed Abdelrazek2 , Mohamed Abdelrazek Al-Senbesy3
Keywords
Related Articles
- EP ID EP570760
- DOI 10.22192/ijcrms.2017.03.11.010
- Views 111
- Downloads 0
Aspirin can prevent Miscarriages
Recurrent miscarriages are post implantation failures in natural conception; they are also termed as habitual abortions or recurrent pregnancy losses. Recurrent pregnancy loss is disheartening to the couple and to the tr...
Pre-clinical toxicological profiling of Siddha formulation Sambirani Poo Kuligai by Acute and Sub-acute toxicity studies in accordance with OECD Guidelines
In recent times use of traditional medicines has been conventionally increased globally. Short-term and long-term toxicity studies with rodents are generally conducted for 14 or 28 days. Results of these studies can help...
Prevalence of hyponatremia in Iranian children diagnosed with seizure: a systematic review and meta-analysis
Objective: The aim of this systematic review and meta-analysis was to evaluate the prevalence of hyponatremia in Iranian children diagnosed with seizure Methods: The searches were conducted in English and Persian by two...
Scientific Evaluation of Sastric Formulation Sangu Chunnam for its Antioxidant potential
To evaluate the antioxidant activity of sangu chunnam in sastric preparation. This assay is based on the qualification of the degradation product of 2 deoxy ribose by condensation with TBA (Elizabeth and Rao, 1990). Hydr...
An update on Anaemia, Iron, Folic acid and Vitamin B 12 in Pregnancy and Postpartum
Anaemia is a decrease in number of red blood cell (RBCs) or less than the normal quality of haemoglobin in the blood. However, it can include decreased oxygen-binding ability of each haemoglobin molecule due to deformity...