Evaluation of Prognostic significance of TF, and β3 integrin by using Immunoflourecent staining method
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 3
Abstract
Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, and adhesion molecules, such as integrin. Current study was aimed to investigate predictive role of β3 integrin and TF protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, and lymph node involvement), by using immunoflourecent staining method. Study done on 40 colorectal cancer samples and their respective resection margins. Current study found that the expression rate of integrin β3 and TF score were significantly higher in patients than in control group, (P<0.001; P<0.001)respectively, I Moreover, when CRC samples breakdown according to histopathological variables present study demonstrated that both of integrin β3 and TF count showed significant correlation with tumor stage (P<0.05 and P<0.05), grade (P<0.05, and P<0.05 ), and L.N involvement (P<0.05, and P<0.05 ) respectively. From above results one can conclude that high expression of β3 integrin and TF are associated with poor prognosis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may consider as a prognostic biomarkers and novel molecular therapeutic targets. Keywords: Angiogenesis, growth factors, β3 integrin, TF protein.
Authors and Affiliations
Ibrahim Abdulmajeed Altamemi
Keywords
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