Abstract

Breast cancer is the second commonest malignancy affecting half a million women worldwide each year. Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to evaluate the level of plasma prolactin & lipid profile in woman developing breast cancer in different stages. A hospital-based randomized cross sectional study was done among 91 consented women diagnosed with breast cancer in different stages. Their blood samples were analyzed for plasma Prolactin, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Chemical analysis performed by means of Hitachi device for prolactin assessment and Accent device for lipid target tests, statistical analysis using ANOVA Test revealed that, there were a Significant increase in the levels of total cholesterol (p = 0.01) and no significant difference in the level of Prolactin, HDL, and LDL cholesterol levels (p = 0.28), (p = 0.39), and (p = 0.29) respectively in a comparison between groups according to different stages. Also despite that, there were a positive correlation between different parameter and the duration of the disease which is represented by years (mean ± SD) (1.52 ± 1.9) only the significant difference appear in the level of total cholesterol (p = 0.002), and no significant difference in the level of Prolactin, HDL, and LDL cholesterol levels (p = 0.59), (p = 0.07), and (p = 0.08) respectively. According to age the correlation reveals that, positive correlations were found with increase age but with no statistical differences for all parameter. Keywords: Breast cancer, plasma prolactin, lipid profile.

Authors and Affiliations