EVALUATION OF PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF FRUIT PEELS OF PUNICA GRANATUM LINN AGAINST ULCERATIVE COLITIS IN RATS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2014, Vol 6, Issue 3
Abstract
The study was designed to evaluate the protective effect of hydro-alcoholic extract of fruits peels of Punica granatum Linn. against acetic acid and trinitrobenzene sulfonic acid (TNBS) induced ulcerative colitis in rats. Acute oral toxicity study was performed to find out the test dose according to OECD guidelines 425 and hydro-alcoholic extract of P. granatum fruit peel (PGPE) was found to be safe at a dose of 2000 mg/kg body weight. The animals pretreated with hydro-alcoholic extract of P. granatum fruit peel (200 mg/kg and 400 mg/kg respectively) significantly restored the altered hematological, biochemical parameters to normal levels when compared with control. The protective effect of P. granatum peel extract was comparable to standard sulfasalazine. The findings of the present study revealed that the hydro-alcoholic extract of P. granatum fruit peel possessed a dose dependent significant inhibitory activity against ulcerative colitis. The results obtained established the efficacy of the Punica granatum fruit peel against inflammatory bowel diseases possibly by its anti-inflammatory and antioxidant properties.
Authors and Affiliations
Ashar Kalangottil, Karunakar Hegde, Naseeb K M
Keywords
Related Articles
- EP ID EP625019
- DOI -
- Views 56
- Downloads 0
IN-VITRO ANTIOXIDANT ACTIVITY AND GC/MS STUDIES ON THE LEAVES OF MENTHA PIPERITA (LAMIACEAE) FROM MOROCCO
The present study was to evaluate the in vitro antioxidant activity and chemical composition of essential oil of Mentha piperita from Morocco. Mentha species from the Lamiaceae family are widely distributed in Morocco an...
STUDY ON CYTOTOXIC EFFECT OF ROOT AND CALLUS EXTRACTS OF MYXOPYRUM SMILACIFOLIUM BLUME
Myxopyrum smilacifolium is a large woody climbing shrub belonging to the family Oleaceae which is known for many medicinal properties. In the present study, initially a short term cytotoxic study (3 hours) with hepatocar...
AN INSIGHT INTO OPHTHALMIC DRUG DELIVERY SYSTEM
Promising management of eye ailments take off effective concentration of drug at the eye for sufficient period of time. Dosage forms are administered directly to eye for localized ophthalmic therapy. Most of the treatmen...
ANTI-FLATULENT STUDIES OF TRADITIONAL MEDICINAL PLANT VITEX NEGUNDO LINN. IN RATS
Vitex negundo is a shrub from Verbenaceae family and is traditionally used in treatment of various disease and disorders. Oil prepared with the juice of leaves of Vitex-negundo is reported to have very useful medicinal p...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE
A new isocratic simple and rapid reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and successively validated for the estimation of ziprasidone hydrochloride monohydrate (ZHM). In this...