Evaluation of Protein C in Nigerian Patients with Sickle Cell Anaemia in Steady State
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 11, Issue 9
Abstract
Background: Sickle cell disease which is considered to be a hypercoagulable state has a worldwide distribution. Protein C is a naturally occurring anticoagulant with anti inflammatory and fibrinolytic properties. Objective: To evaluate the level of Protein C in Nigerian Patients with sickle cell anaemia (SCA) in steady state. Methods: This is a comparative cross sectional study carried out in Ibadan on 40 HbSS patients in steady state attending Haematology clinic at University College Hospital, Ibadan and 40 age and sex matched healthy normal HbAA control. Protein C was assayed with Amax Destiny Coagulometer using clot based method. Liver function test (LFT) was done with Hitachi 912. Results: A significant decrease in Protein C was found in HbSS patients in steady state (median value 62.8%) compared with HbAA control Subjects (74.6%) (p = 0.00). There was no significant difference in the LFT of the HbSS patients and the control HbAA subjects, P > 0.05 in all the parameters measured. (Alanine Transaminase (ALT), P = 0.82; Albumin, P = 0.12; Total Protein, P =0.37). Conclusion: The low Protein C level observed in HbSS patients in steady state may not be due to hepatic dysfunction as LFT in the subjects were found to be normal.
Authors and Affiliations
A. A. Ibijola, O. T. Ojo, W. A. Shokunbi
Keywords
Related Articles
- EP ID EP340300
- DOI 10.9734/BJMMR/2016/21539
- Views 66
- Downloads 0
Radiologic Evaluation of Marginal Bone Loss in Delayed vs. Immediate Loaded Implants –18 Month Results of a Prospective Comparative Study
Aim: To compare the amount of bone loss (if any) at the mesial and distal sides in delayed and immediate loaded dental implants. Study Design: Total 20 partially edentulous (anterior region of Maxilla) patients were rand...
A Systematic Review on Prognostic Indicators of Acute Liver Failure and Their Predictive Value for Poor Outcome
Aims: To systematically identify and summarize prognostic indicators in patients with acute liver failure and to evaluate their predictive value. To analyse a wide spectrum of indicators used worldwide for prediction of...
Prevalence of Glucose -6- Phosphate Dehydrogenase (G-6-PD) Deficiency in Sokoto: Liver Function and Oxidative Stress Biomarkers in Deficient Individual
Background: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing Nicotinamide adenine dinucleotide phos...
Bacteriological and Cytokine Profiles for Women Using Hormonal Contraceptive Drugs
Background: Hormonal contraceptives that contain estrogen and progesterone alter the genital tract epithelial configuration which has been suggested to be associated with shifts in the vaginal flora, changes that occurri...
Antioxidant Potential of Polyphenol Rich Extract from Hibiscus sabdariffa
Aims: Hibiscus sabdariffa is a medicinal plant species that is consumed for its health benefits in Africa, therefore this study investigated the antioxidant properties of Hibiscus polyphenolic rich extract (HPE), prepare...