Evaluation of Protein C, Protein S and Antithrombin in Patients with Preeclampsia

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Evaluation of Protein C, Protein S and Antithrombin in Patients with Preeclampsia

Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 5

Abstract

Abstract: The present study aims to measure protein C (PrC), free protein S (fPrS)and antithrombin (AT)in patients with preeclampsia (PE) and compare them with pregnant and non-pregnant controls (regarding PrC and fPr S)and to study the association between some haematological parameters with the level of natural anticoagulant in patients with preeclampsia . The case control study was done for fifty patients with preeclampsia, fifty for each healthy age matched pregnant and non-pregnant controls. Patients were diagnosed according to the diagnostic criteria of PEand were admitted to Al-Batool, Al-Khansaa and Al-Salaam Teaching Hospitals in Mosul between December 2012 and May 2013.Comparison between patients and pregnant controls was done in the natural anticoaulants: PrC level, fPr S level and AT level. PrC, fPr S level were done in non-pregnant controls as well for more confirmation. Other haematological parameters including platelet count (PLT), prothrombine time (PT) , activated partial thromboplastine time (APTT), fibrinogn level (FBG) and (D-dimer) where assessed in these patients to uncover any relative association with these natural anticoagulants level as well ,overall impact on the severity of the disease. A larger proportion of studied patients 70% were with severe PE, while 30% of them were with mild PE. PrC level was recognized to show significant decrease in patients with PE when compared to both pregnant and non-pregnant women. Free PrS level was significantly lower in patients with PE and control pregnant women when compared to non-pregnant controls ,yet, no significant difference was existed between patients and pregnant control AT was significantly lower in patients with PE as compared to the control pregnant group .Low AT was particularly in patients with severe PE and those with low PLT count and this was the only deduced association between the evaluated natural anticoagulants and the other haematological parameters in the study . Severe PE patients were recognized with a more significant reduced AT , FBG , and PLT as well more frequent shortened APTT and positive D-Dimer as compared to either mild and/ healthy pregnant groups .1. Plasma PrC level ,plasma fPr S level ,serum AT and plasma FBG level were decreased in PE patients and were significantly lower when compared to the control pregnant women apart from fPrS level which had no significant difference between both groups. 2. AT level show a significant association with PLT count . 3.Beside the known low platelet sign of sever PE, any of the following parameters (Low AT level , low FBG level , positive D-dimer , shortened APTT ) can be considered as an estimating factor of the severity of PE. Keywords:preeclampsia (PE),protein C (PrC), free protein S (fPrS)and antithrombin (AT)

Authors and Affiliations

Mae Ghanim Azeez, Muna Kashmoola

Keywords

preeclampsia (PE) protein C (PrC) free protein S (fPrS)and antithrombin (AT)

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