Evaluation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats
Journal Title: Majallah-i jarrāḥī-i ustukhvān va mafāṣil-i Īrān - Year 2018, Vol 16, Issue 2
Abstract
Background: Osteoarthritis (OA) is widespread degenerative joint disease. Although many therapeutic policies exist, no clear preventive remedy exists. Due to various side effects caused by conventional medication; we aim to evaluate the effect of leaf of Psidium guajava essential oil on animal model of OA. Methods: This 8-week animal model study was conducted on 25 male rats with induced osteoarthritis with collagenase. The rats were divided into 5 groups randomly, the first group that serves as negative control group and received intra-articular injections of saline, the second group received olive oil, the third group intra articular(IA)Hyalgan, the fourth group received low dosage (25 λ) essenal oil of Psidium guajava L. leaf, and the last group which received high dosage (50 λ) essenal oil of Psidium guajava L. leaf. All groups received their medicaon for 4 weeks. After 8 weeks from beginning of study, all of the animals were euthanized with CO2 and samples harvested. All the samples underwent histopathological and radiological evaluation and data were collected and analyzed by Kruskal-Wallis nonparametric test (distribuon free) by SPSS version 23.00. Results: In histopathological findings illustrate a considerable difference between high dose (50λ) treatment group and the control group. Moreover; in radiographic findings, significant difference was observed between groups in evaluation of distribution in joint space width. (P value =0.0001) Conclusion: Essential oil of Psidium guajava L. leaf has a considerable positive effect on osteoarthritis.
Authors and Affiliations
Nader Tanideh, Mohammad Amin Rostami Nasab Mohammad Amin Rostami Nasab, Ida Hasssanpour, Omid Koohi Hosseinabadi, Maryam Mojahed, Sara Sadat Nabavizadeh
Keywords
Related Articles
- EP ID EP451761
- DOI -
- Views 72
- Downloads 0
Thermostatic Mateiral in structure of Orthosis (A Brief Note)
The use of orthosis in many musculoskeletal conditions and neurologic defects is mandatory. The making of orthosis is usually, with thermoplastic material. Such material can be divided into 3 categories depending on the...
Evaluation of the Effect of Hydroalcoholic Extract of Psidium Guajava Linn. (Myrtaceae) Leaf with Synovium-derived Stem Cells and Platelet Rich Plasma (PRP) on Induced Osteoarthritis of the Knee in Male Rats
Background: The available synthetic drugs for treatment of Osteoarthritis (OA), a degenerative arthritis, have serious side effects and low efficacy. Therefore, using herbal medicines, with mesenchymal stem cells, as an...
Reverse "Ponseti" Casting in Treatment of Congenital Vertical Talus A Clinical Trial
Background: The most common method of treatment for vertical talus is the extensive soft tissue release. A minimally-invasive method based on Dobb's serial casting (Reverse Ponseti) was introduced 15 years ago and has yi...
Frequency of Cervical Radiculopathy in Patients with Carpal Tunnel Syndrome
Background: Carpal tunnel syndrome (CTS) is the most common form of localized peripheral neuropathy. CTS and cervical radiculopathy (CR) often co-occur and is known as double crush syndrome (DCS). Aim: This study aimed a...
Concurrent Use of Theranekron with Hydroxyapatite on Bone Healing in Rabbit Model: Radiographic and Histologic Evaluation
Background: Nowadays, bone grafting is used in both human and veterinary orthopedics to stimulate fracture healing, accelerate joint union, and restore bone defects. In such procedures, orthopedic surgeons are studying a...