Evaluation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats
Journal Title: Majallah-i jarrāḥī-i ustukhvān va mafāṣil-i Īrān - Year 2018, Vol 16, Issue 2
Abstract
Background: Osteoarthritis (OA) is widespread degenerative joint disease. Although many therapeutic policies exist, no clear preventive remedy exists. Due to various side effects caused by conventional medication; we aim to evaluate the effect of leaf of Psidium guajava essential oil on animal model of OA. Methods: This 8-week animal model study was conducted on 25 male rats with induced osteoarthritis with collagenase. The rats were divided into 5 groups randomly, the first group that serves as negative control group and received intra-articular injections of saline, the second group received olive oil, the third group intra articular(IA)Hyalgan, the fourth group received low dosage (25 λ) essenal oil of Psidium guajava L. leaf, and the last group which received high dosage (50 λ) essenal oil of Psidium guajava L. leaf. All groups received their medicaon for 4 weeks. After 8 weeks from beginning of study, all of the animals were euthanized with CO2 and samples harvested. All the samples underwent histopathological and radiological evaluation and data were collected and analyzed by Kruskal-Wallis nonparametric test (distribuon free) by SPSS version 23.00. Results: In histopathological findings illustrate a considerable difference between high dose (50λ) treatment group and the control group. Moreover; in radiographic findings, significant difference was observed between groups in evaluation of distribution in joint space width. (P value =0.0001) Conclusion: Essential oil of Psidium guajava L. leaf has a considerable positive effect on osteoarthritis.
Authors and Affiliations
Nader Tanideh, Mohammad Amin Rostami Nasab Mohammad Amin Rostami Nasab, Ida Hasssanpour, Omid Koohi Hosseinabadi, Maryam Mojahed, Sara Sadat Nabavizadeh
Keywords
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