Evaluation of Response in Locally Advanced Head and Neck Carcinoma after Short Course Palliative Hypofractionated Radiotherapy.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Introduction: Advanced stage of head and neck carcinomas patients are inoperable and have shorter life span with poor quality of life. The aim of this study is to evaluate the treatment response at the primary and nodal sites, improvement of symptoms and toxicity after a short course hypofractionated radiotherapy schedule. Methods: Fifty Patients With Advanced Stage Head And Neck Cancers With Hard Fixed Neck Nodes Were Included In This Study. All Patients Included Were Previously Untreated, Histopathologically Proven Squamous Cell Carcinoma And ECOG Performance Between 2 & 3, Received Short Course Hypofractionated Radiotherapy (20Gy/5fraction/4Gy Per Fraction/5 Days In A Week). Result: Pain And Dysphagia Were Most Common Presenting Complaints. Evaluation Was Done At 15th And 30th Day After Completion Of Treatment Using WHO Criteria And Toxicities Were Assessed Using RTOG Criteria. Complete Response(CR) And Partial Response(PR) Was Achieved In 2 And 47 Patients Respectively. One Patient Had Stable Disease. Grade II And III Toxicities Were Observed In Most Patients. None Of The Patients Had Progressive Disease Or Grade IV Toxicities. Conclusion: Hypofractionated Radiotherapy Should Be Included As A Means Of Palliation In Advanced Inoperable Head And Neck Cancer Patients To Achieve A Significant Symptom Relief.
Authors and Affiliations
Dr Abhishek Sharma
Keywords
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