Evaluation of role of priming agents in salicylic acid peel: A comparative study
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 2
Abstract
Introduction Salicylic acid is increasingly used as a superficial peeling agent for acne Widespread use has caused increasing awareness about the adverse events associated with SA like erythema exfoliation itching redness etc Appropriate use of priming agents like retinoids hydroquinone etc can help in reduction of ADRs and can affect final treatment resultAim Evaluation of efficacy and safety of salicylic acid SA peel with or without priming agents in patients of acneMethodology A prospective randomized openlabel parallelgroup study was carried out in patients with acne Total 72 patients were randomized in to three groups A B and C to receive 30 salicylic acid SA peel with either 005 tretinoin or 4 hydroquinone or without any priming agent Objective and subjective assessment in improvement in acne was compared For safety analysis all reported adverse drug events were comparedResults Mean age of patients was 2246plusmn532 years Both noninflammatory and inflammatory acne lesions reduced with SA peel in all three groups Improvement in total acne score is significantly higher in SA peel with priming agents plt005 The change in total acne score Week 012 was 8145 with SA alone 943 with isotetinoin and 902 with hydroquinone priming plt005 Total adverse event reported were 105882 4 2353 and 31765 in SA peel without priming agent with isotetinoin and with hydroquinone respectively Rate of occurrence of adverse events was significantly high in SA without priming agent plt005 Mean visual analogue score was 9147 9431 and 8346 in group A B and C respectively SA peel with priming agent was rated as significantly more effective by patients rather than SA without priming agent plt005Conclusion Appropriate priming agents should always be used with superficial peeling agents like SA in management of acne which enhances the effectiveness and reduces the adverse effects of therapyKeywords Acne Salicylic acid peel Priming agents Tretinoin Hydroquinone
Authors and Affiliations
Purna Pandya, Ishan Pandya, Dhwani Rathod, Bela Padhiyar
Keywords
Related Articles
- EP ID EP488867
- DOI 10.18231/2581-4729.2018.0021
- Views 104
- Downloads 0
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