Evaluation of Root Extract of Acacia nilotica on Haematological and Lipid Profile in Rats
Journal Title: European Journal of Medicinal Plants - Year 2016, Vol 17, Issue 4
Abstract
Aim: Acacia nilotica root has been used for different medicinal purposes wherever the plant is found in Nigeria. This study was designed to evaluate the effects of Acacia nilotica aqueous root extract on hematological parameters and lipid profile in rats. Place and Duration of Study: Research work carried out by the author in the National Institute for Pharmaceutical Research and Development (NIPRD), Abuja and department of Medical Biochemistry, Faculty of Basic Medical Sciences, University of Abuja between June and December 2015. Methods: Forty eight Wistar rats (180.00 ± 20 g) separated into 24 females and 24 males, were randomly divided into four groups of six rats per group. Group 1, served as the control and received 10 ml/kg body weight of distilled water, while rats in groups 2, 3 and 4 received extract at 125, 250 and 500 mg/kg body weight orally, respectively for 28 days. Blood was collected via cardiac puncture on day 29 (after the rats were sacrificed) into EDTA bottles (haematology profile) and plain bottles (lipid profile). Phytochemical screening and acute toxicity were also carried out. Results: The extract at 500 mg/kg body weight, produced significant increase in red blood cells (RBC), white blood cells (WBC), haemoglobin (Hb) and packed cell volume (PCV) compared to the control in male rats. In female rats, the dose of 250 mg/kg b.wt of the extract produced significant increase in Hb and PCV. There was significant decrease in total cholesterol and triglycerides at 500 mg/kg b.wt in both male and female rats. Conclusion: The results of this study showed that aqueous root extract of Acacia nilotica can be used to correct anaemia by increasing PCV and also prevent hypercholesterolemia by reducing serum cholesterol.
Authors and Affiliations
Alli Lukman Adewale
Keywords
Related Articles
- EP ID EP349604
- DOI 10.9734/EJMP/2016/31262
- Views 95
- Downloads 0
In vitro Modulation of Pancreatic Insulin Secretion and Extra Pancreatic Insulin Action, Enzymatic Starch Digestion and Protein Glycation by Terminalia chebula Extracts
Aim: Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Study Design: Using multiple in vitro models; this study was designed to investigate the efficacy and mode of a...
Cytotoxicity and Anti-microbial Activity of Aqueous Methanolic Extract of Zingiber officinale Roscoe (Zingiberacae)
Aim: The current study evaluates the cytotoxic Activity of aqueous methanolic extract from Ginger (Zingiber officinale Roscoe, Zingiberacae) against five human cancer cell lines (lung carcinoma cell line) (A549-1), Caco-...
Antimicrobial Activity of Phenylpropanoyle from the Rhizome of Zingiber officinale Roscoe (Zingiberaceae)
Aim: This study was carried out to determine the phytochemical and the antimicrobial activities of Zingiber officinale (Zingiberaceae) Rhizome. Methodology: The air-dried and powdered rhizome (1.0 kg) of Z. officinale wa...
Moringa oleifera Leaf Prevents Oxidative Stress in Wistar Rats
Background: It is believed now in some group of people that Moringa oleifera is medicinal in nature. People take it in any form to cure various clinical conditions. A number of clinical conditions have been linked to oxi...
Antimicrobial Effects of Leaves of Eucalyptus camaldulensis on Some Microbial Pathogens
Background: Plants are important sources of medicinal materials and have been in use since ancient times. Although numerous plants have been explored for their medicinal properties, there still remains much to be studied...