Evaluation of salivary contents in oral cancer: A preliminary study
Journal Title: International Journal of Dentistry Research - Year 2018, Vol 3, Issue 1
Abstract
Introduction: Salivary levels have been measured in many infections, autoimmune or psychiatric diseases and in various cancers. Salivary components such as kallikrein, epidermal growth factor, CA-125and p53 are used as tumor markers in breast, ovary or lung malignancies. There is short of studies using saliva as a diagnostic fluid for oral cancer. Aim and objective: Estimation of salivary total protein, sialic acid and total sugar in the oral cancer patients. Material and method: Unstimulated saliva was collected from 50 controls (Group I) and 50 oral squamous cell carcinoma patients (group II) and sialic acid, total protein, and total sugar were estimated and compared with the different histological grades. Statistical analysis and Results: Student’s t test and ANOVA was performed for the statistical analysis. The level of salivary protein was lower in Group II compared to Group I. The level of total sugar, free sialic acid and protein bound sialic acid was elevated in Group II than Group I. The total protein and sugar and sialic acid were significantly high in well differentiated squamous cell carcinoma. Conclusion: We conclude that analysis of saliva can help in early diagnosis of oral cancer.
Authors and Affiliations
Mohd Saleem, Balasundari Shreedhar, Pradkhshana Vijay, Mala Kamboj, Somi Fatima, Faizal Ali
Keywords
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- EP ID EP506710
- DOI 10.31254/dentistry.2018.3105
- Views 38
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