Evaluation of Serum Cystatin C in Acute Kidney Injury
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 2
Abstract
Background: Serum Creatinine, widely used in diagnosing the presence of acute kidney injury, is a suboptimal biomarker. The purpose of our study was to measure serum Cystatin C in patients of acute kidney injury and to correlate with the serum Creatinine and estimated glomerular filtration rate (eGFR). Methods: The study was conducted in patients of acute kidney injury over one and a half year period. Serum Cystatin C was measured in each case at the time of initial work up for diagnosis of acute kidney injury and results were correlated with the simultaneously taken serum Creatinine and with eGFR estimated by four variable MDRD and CKD-EPI equation based on serum Cystatin C and serum Creatinine. Results: Study included 105 patients of acute kidney injury. The mean age of patients was 44.0±16.2 years. The male to female ratio was 3:1. Medical conditions constituted 88% of patients and septicaemia (51%) was the most common precipitating factor for acute kidney injury. The mean values of serum Cystatin C and serum Creatinine were 2.98±1.64 mg/L and 3.8±2.5 mg/dL respectively. A positive correlation was seen between serum Cystatin C and serum Creatinine. A good correlation was observed with e GFR. On multivariate logistic regression analysis it was seen that with increase in serum Cystatin C, serum Creatinine and age, there would occur a decline in GFR. Conclusion: Serum Cystatin levels are elevated in patients of acute kidney injury. There is a significant correlation of serum Cystatin C with serum Creatinine and estimated GFR.
Authors and Affiliations
Gurbhej Singh,Harminder Singh Pannu, Jashan Sandhu,Jasvinder Singh Sandhu,Navjot kaur Bajwa, Suman Sethi, Simran Kaur
Keywords
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