EVALUATION OF SOLUBILITY OF SIMVASTATIN USING β-CYCLODEXTRIN BY SOLID DISPERSION TECHNIQUE

Journal Title: International Journal of Biomedical Research - Year 2010, Vol 1, Issue 2

Abstract

Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-β cyclodextrin dispersions were prepared with a view to study the influence of β-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of β-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when β-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of rug and carrier.

Authors and Affiliations

Punitha S, Senthil KL

Keywords

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  • EP ID EP86007
  • DOI http://dx.doi.org/10.7439/ijbr.v1i2.58
  • Views 199
  • Downloads 0

How To Cite

Punitha S, Senthil KL (2010). EVALUATION OF SOLUBILITY OF SIMVASTATIN USING β-CYCLODEXTRIN BY SOLID DISPERSION TECHNIQUE. International Journal of Biomedical Research, 1(2), 44-54. https://europub.co.uk/articles/-A-86007