EVALUATION OF SOLUBILITY OF SIMVASTATIN USING β-CYCLODEXTRIN BY SOLID DISPERSION TECHNIQUE
Journal Title: International Journal of Biomedical Research - Year 2010, Vol 1, Issue 2
Abstract
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin-β cyclodextrin dispersions were prepared with a view to study the influence of β-CD on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of β-CD as carrier by Physical mixture, solvent evaporation method, Kneading method and Fusion Method. They were evaluated for drug content, moisture content, FTIR spectral studies, solubility, in-vitro dissolution and release kinetics. The solubility profile indicated that there is increase in solubility of Simvastatin when β-CD concentration is increased. The solid dispersion complex of drug (1:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions (1:1 and 1:3). This in turn can improve the bioavailability. FT-IR shows the complexation and compatibility of rug and carrier.
Authors and Affiliations
Punitha S, Senthil KL
Keywords
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- EP ID EP86007
- DOI http://dx.doi.org/10.7439/ijbr.v1i2.58
- Views 197
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