Evaluation of some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid before and after chemotherapy in stomach cancer
Journal Title: Medical Science and Discovery - Year 2016, Vol 3, Issue 1
Abstract
Objective: It was aimed to compare the some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid levels in patients with stomach cancer before and after chemotherapy to the healthy controls.Material and Methods: Forty-eight patients with stomach adenocarcinoma and 20 healthy controls, totally 68 subjects were used. Blood samples were taken from all patients before and after chemotherapy and controls to analyse the levels of tumor markers (CA 125, CA 15-3, CA 19-9, CEA), acute phase proteins (CRP and fibrinogen) and SA (sialic acid), LSA (lipid bound sialic acid).Results: Before chemotherapy the serum levels of CA 125, CA 15-3, CA 19-9, CEA SA, LSA, CRP and fibrinogen (107.30 U/ml, 65.74 U/ml, 295.86 U/ml, 108.57 ng/ml, 199.60 mg/dl, 41.89 mg/dl, 86.03 mg/l and 469.42 mg/dl ) were higher than after chemotherapy group (36.46 U/ml, 34.00 U/ml, 100.18 U/ml, 20.20 ng/ml, 87.67 mg/dl, 31.06 mg/dl, 57.04 mg/l and 379.04 mg/dl) and the controls (8.64 U/ml, 21.65 U/ml, 21.52 U/ml, 2.77 ng/ml, 73.75 mg/dl, 27.47 mg/dl, 2.37 mg/l, 303.5 mg/dl).Conclusion: The serum levels of SA and LSA may be considered the indicators of poor/good prognosis of stomach cancer. CRP and fibrinogen are suggested as available biomarkers for diagnosis and prognosis in patients with stomach cancer.
Authors and Affiliations
Aysegul Cebi, Handan Mert, Nihat Mert
Keywords
Related Articles
- EP ID EP520467
- DOI -
- Views 72
- Downloads 0
A rare cause of acute abdomen: Spontaneous uterine rupture by percrete placenta
The uterine rupture during pregnancy is one of the most serious complications, increase morbidity and maternal and fetal mortality. The uterine rupture by percreta placenta is very rare situation. In this article, the ca...
Impact of menopause on quality of life: A cross sectional study in menopausal females in the north of Jordan
Aims: Menopause can severely effects the somatic, urogenital and psychological aspects of life, our aim is to find out the Health Related Quality of Life in female patients with menopause in a tertiary care hospital. Met...
A phosphate enema-associated chemical colitis
Enemas are widely used in patients with poor colon cleansing in preparation for colonoscopy. Although they are regarded as having minimal side-effects, enemas can give rise to severe side-effects due to the chemical subs...
An extremely rare complication after appendectomy in a child: indicators for omental abscess, CRP and Leukocytosis
A 14 year-old male child underwent appendectomy, and partial omentectomy with the indication of perforated appendicitis. Despite antibiotic therapy at postoperative sixth day, purulent discharge started to ooze from the...
Epidural blood patch for the treatment of post dural puncture headache in pregnant women
Objective: Postdural puncture headache (PDPH) is still a considerable problem and it is one of the most common complications of neuro axial anesthesia. Efficiency of the blood patch performed for the patients...