Evaluation of Subject Response to Antipsychotics - Subjective Aspect and Related Clinical Correlates
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 3
Abstract
Aim: The aim of this study is to assess the subjective response to antipsychotics in patients with schizophrenia and to assess the related factors such as psychopathology, side effects, insight, and treatment variables. Methodology: A total of 60 patients with schizophrenia were randomized to treatment with risperidone (n-30) or haloperidol (n = 30) daily. Efficacy was assessed by the improvement of psychotic symptoms, measured on the positive and negative syndrome scale. The safety and tolerability were evaluated with the extrapyramidal symptom rating scale, the UKU side effect rating scale, and Insight and Treatment Attitude Questionnaire. Results: Comparing haloperidol group and risperidone group for variables such as sex, age, duration of treatment, literacy level, and drug-free duration before admission was not statistically significant. Hence, both groups are comparable. Haloperidol group had the number of dysphoric patients (21), and risperidone group had only 8 patients who had dysphoria (Chi-square P < 0.01). In psychopathology, subjective response was more dysphoric when paranoid scores were high (significant two-tailed −0.00). In the final assessment total, psychopathology scores were high if dysphoria is high and if psychopathology scores were low and the dysphoria is also low (significant two-tailed −0.00). Dysphoria scores are high if insight is low, and dysphoria scores are low if insight is good. Dysphoria scores increase with increasing side effects and decrease with decreasing insight (significant two-tailed −0.00). Conclusion: Subjective response to risperidone is better than haloperidol. If there is the initial dysphoric response, the treatment response is reduced with low insight and high psychopathology in the dysphoric group.
Authors and Affiliations
V Geethaanjali, C Jayakrishnaveni
Keywords
Related Articles
- EP ID EP479844
- DOI -
- Views 100
- Downloads 0
A Study of Duodenal Ulcer Perforation Post-operative Outcome in A Tertiary Center
Introduction: Time trends in the epidemiology of perforated peptic ulcer disease reflect complex, multifactorial etiologies. Based on today’s fast and instant lifestyle, it is evident that the epidemiology of peptic ulce...
Screening for Acanthosis Nigricans in Type 2 Diabetes Mellitus - It’s Time for Reinforcement
Background: Acanthosis nigricans is a well-known external marker for insulin resistance, obesity and type 2 diabetes mellitus (T2DM). The prevalence of acanthosis varies among different ethnic groups. Aim: The aim of the...
Role of Intratympanic Dexamethasone Injection as a Treatment Choice in Patients with Immune‑mediated Sensory Neural Hearing Loss - A Clinical Study
Background: Sensorineural hearing loss (SNHL) is not an uncommon condition encountered in ENT practice. Once developed in patients, it causes severe handicap that affects their job, family life, and social life. Therefor...
A Retrospective Analysis of Hysterolaparoscopy Findings of Unexplained Infertility Patients in a Tertiary Care Hospital
Abstract Introduction: Infertility, according to the WHO, is defined as failure to conceive after 12 months or more of regular unprotected sexual intercourse. As routine examinations and procedures are often unable to di...
Clinical Study of Splenic Trauma in Blunt Injury Abdomen
Introduction: Motor vehicle accidents account for most of the cases of splenic injury. Although protected under the bony ribcage, the spleen remains the most commonly affected organ in blunt injury to the abdomen in all...