Evaluation of synergistic antimicrobial activity of Gemifloxacin with Linum usitatissimum seed oil
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 6
Abstract
Gemifloxacin and Linseed (Linum usitatissimum L.) oil has individual in-vitro antimicrobial activity against a wide range of gram-negative and gram-positive microorganisms. To reduce dose dependent side effects and the development of drug-resistance by an antibiotic when used alone, in accordance with the maintenance of the effectiveness, the alternative approach nowadays is to go for combinations of antibiotic required for the treatment along with any other suitable agent for minimization of the above problems. This study involved an initial approach to evaluate the synergistic antimicrobial effects of gemifloxacin with linseed oil. The physicochemical properties of the oil determined were color, odor, specific gravity, acid value, iodine value and saponification value. Phytochemical analysis revealed that Linseed oil contains fats, flavonoids, glycosides, phenols and tannins. Combined antimicrobial effects of both gemifloxacin and linseed oil were then analyzed in different combinations using the microbial strains of Staphylococcus aureus, Bacillus subtillus, Escherichia coli and Shigella boyedi. From the results, it was concluded that linseed oil synergies the antimicrobial potential of gemifloxacin when used simultaneously in various combinations.
Authors and Affiliations
Yogesh Joshi, Ruchika Garg, Divya Juyal
Keywords
Related Articles
- EP ID EP49588
- DOI -
- Views 220
- Downloads 0
Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis
Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of deaths, especially in western countries. Its etiology is known to be a combination of hereditary, environmental,...
Antiplasmodial and antimicrobial potential of Canthium subcordatum extracts and isolates
Phytochemical studies on the stem bark of Canthium subcordatum afforded eight known compounds: β- sitosterol (1), ursolic acid (2), cerbinal (3), quinovic acid (4), Cerberinic acid (5), 3-O-β-Dglucopyranosylquinovic aci...
Review on pharmacological activities and phytochemical constituents of Phyllanthus niruri (Amarus)
Phyllanthus amarus Schum and Thonn (Euphobiaceae); is found in tropical and sub-tropical region of the world. It grows as a weed in moist abandoned land. It has various applications in tradition and folk medicine for t...
Quality control constraint of Guizotia abyssinica Cass, source of medicinally useful edible oil seeds
Introduction: Guizotia abyssinica Cass. branched herb with erect, stout stem, commonly known as Ramtil or Niger seed. Seeds are the rich source of oil with high nutritional index. Traditionally the seed powder is used a...
Characterization and anti-oxidant activity of Cucurbita maxima Duchesne pulp and seed extracts
The study aimed to characterize phytochemical composition of C. maxima seeds and pulp. The ethanol and aqueous extract of C. maxima seeds and pulp were done using percolation method. The phytochemical composition of et...