Evaluation of Tephrosia purpurea for anti hyperlipidemic activity in high fat induced rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 4
Abstract
The anti-hyperlipidemic effect of methanolic extract of leaves of Tephrosia purpurea (T.purpurea) was tested in high fat diet induced hyperlipidemic rat models. Here, chronic hyperlipidemia was induced by feeding fat diet for 21 days. The hyperlipedemic rats are grouped and Treated with fenofibrate (5mg/kg), T.purpurea extract, (200 and 400 mg/kg, p.o). The plant extract treated groups are significantly reduced the hyperlipidemia i.e., decreased levels of serum Total Cholesterol, Trigly cerides, Low Density Lipoprotein Cholesterol (LDL-C), and increase of serum High Density Lipoprotein Cholesterol (HDL-C) whencompared to vehicle control and standard drug Fenofibate (5 mg/kg). The results demonstrated that methanolic extract of leaves of T.purpurea possessed significant antihyperlipidemic activity.
Authors and Affiliations
Raghavendra H. G
Keywords
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