EVALUATION OF THE ACUTE BIOCHEMICAL CHANGES AND INCIDENCE OF VIRAL AND MYCOBACTERIUM MANIFESTATION ASSOCIATED WITH CHOP WITH OR WITHOUT RITUXIMAB IN DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 9
Abstract
Background: Diffuse large B-cell Lymphoma is a major hematologic cancer and if left untreated it may lead to death. Cyclophosphamide, hydroxyrubicin, Oncovin Prednisolone and Rituximab- Cyclophosphamide, hydroxyrubic in Oncovin and Prednisolone are gold standard chemotherapy regimen in overall survival of DLBCL patients. The CHOP and R-CHOP produces significant adverse effects and prolong hospital stay. Aims and Objective: This study was conducted to determine the changes in biochemical disturbances and the incidence of varicella zoster virus infection, mycobacterium infection and infusion reaction induced by CHOP and R-CHOP in DLBCL patients. Changes in metabolic profile and incidence of VZV and tuberculosis correlated with dose intensity ratio, the findings of this study will be helpful in choices for the physician to discontinue therapy or delaying treatment. Method: Baseline readings of metabolic profile were taken and treated as control readings of 31 patients. Post-treatment readings of aforesaid parameters were taken after 20 days and treated as post-treatment group. Means readings were compared with common terminology criteria for adverse events v3.0 2006 (CTCAE) to find the differences in biochemical parameters at baseline and 20 days post-treatment. Results: Patients treated with CHOP therapy showed a significant difference of Alkaline Phosphatase ALP (p-value 0.009), direct bilirubin (p-value 0.034) and serum glutamic-pyruvic transaminase (p-value 0.004) was observed before and after the treatment. Whereas patients treated with RCHOP had only 3 (19%) infusion reaction as per the Common Terminology Criteria for Adverse Events (CTCAE) 2006. Whereas 2 (12%) of patients had herpes simplex viral infection after the RCHOP chemotherapy. Patients treated with CHOP 1 (6.6%) had HSV manifestation. Bacterial Pneumonia was only 1 (5%) reported after RCHOP cycle. Only 1 (5%) had CMV manifestation after the rituximab containing therapy. Conclusion: In summary, subjects at baseline metabolic impairments should be corrected rigorously at the start of chemotherapy of CHOP or R-CHOP cycles that may leads to life threatening renal and hepatic toxicities. R-CHOP is well tolerated than CHOP in term of toxicities.
Authors and Affiliations
Dr. Kashif Ali
Keywords
Related Articles
- EP ID EP630796
- DOI -
- Views 148
- Downloads 0
GLC STUDY AND BIOLOGICAL ACTIVITIES OF THE VOLATILE OIL COMPONENTS OF SOME IN VIVO AND IN VITRO TISSUES OF FOENICULUM VULGARE MILL. VAR. VULGARE
Foeniculum vulgare Mill. is a wild, annual herb native to the Mediterranean area. The plant is commonly known as the bitter fennel or the common fennel, known in Egypt as "shamar".[1] This plant is rich in important phar...
CURCUMIN AMELIORATES THE HAZARD EFFECT OF PRENATAL BETAMETHASONE ADMINISTRATION ON THE FETAL ADRENAL GLAND OF ALBINO RATS
The present study aimed to investigate the possible adverse effects of maternally injected betamethasone on the developing adrenal gland of the albino rat (Rattus norvegicus) fetuses. Another aim was to ameliorate these...
THE PREVALENCE OF CONGENITAL MALFORMATIONS OF DERMATOGLYPHS OF NIGERIANS IN TERTIARY INSTITUTIONS IN RIVERS STATE.
Background: Dermatoglyphic patterns of the digits of the hands are so significant and helpful in personal identification as no two individuals on earth have exactly same patterns, not even identical twins. However, there...
THE STUDY OF HISTOLOGICAL PARAMETERS IN THE DEVELOPMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE IN RATS
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease over the world, and it persists at a high prevalence. NAFLD is characterized by a spectrum of histopathological findings, ranging from si...
RECONSTRUCTIVE - RESTORATIVE SURGERY FOR LOCALLY ADVANCED TUMORS OF THE OROPHARYNGEAL ZONE
Reconstructive surgeries for locally advanced malignant head and neck tumors are an integral part of rehabilitation activities and are aimed at improving cosmetic and functional results. Skin-muscular flaps on the leg wi...