EVALUATION OF THE ANTIBACTERIAL ACTIVITY AND DETERMINATION OF POLYPHENOLS AND FLAVONOIDS CONTENTS OF MOROCCAN CORIARIA MYRTIFOLIA EXTRACTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: This study aimed to evaluate the antibacterial activity of Coriaria myrtifolia’s extracts from two Moroccan regions and to determine their total polyphenol’s and flavonoid’s contents.Methods: The disk diffusion method was used to evaluate antimicrobial activity. Folin Ciocalteu and aluminum trichloride methods were used to determine the Total polyphenol’s and flavonoid’s contents respectively.Results: The ethyl acetate extracts induced inhibition zone diameters of 20.3 mm and 22.6 mm for samples collected from Bab Berred (BB) and of 20 and 19 mm for those from Oued Al Koub (OK) respectively in Mycobacterium aurum and Mycobacterium smegmatis. Inhibition zone diameters of Pseudomonas aeruginosa were only 12.3 and 10 mm respectively for BB and OK ethyl acetate extracts. The polyphenols and flavonoids contents were respectively 609µg/ml and 105µg/ml in the OK ethyl acetate extract and only 475 and 6 µg/ml in the dichloromethan extract.Conclusion: The antibacterial activity of tested extracts depends on the extract’s nature, the bacterial strain and the plant’s geographical provenance. The ethyl acetate’s extract of C. myrtifolia from BB was the most active. Mycobacterium aurum and M. smegmatis were the most sensitive to Coriaria myrtifolia’s extracts and P. aeruginosa was the most resistant. The polyphenol’s and flavonoid’s contents were different depending on the extract’s nature and the plant’s provenance. Valorization of Coriaria myrtifolia and evaluation of its biological and phytochemical activities will enable us to screen and test new natural antibacterial molecules in general and antimycobacterial agents in particular.Â
Authors and Affiliations
Maha Hafse, Abdellah Farah, Kawtar Fikri Benbrahim
Keywords
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