Evaluation of the anticancer potentials of Origanum marjorana on fibrosarcoma (HT-1080) cell line
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2014, Vol 4, Issue 0
Abstract
Objective: To evaluate the potential anticancer activity of Origanum majorana (marjoram) (O. marjorana) on the fibrosarcoma cancer cell line HT-1080 through various in-vitro assays. Methods: Crude extracts were prepared from O. marjorana using ethanol, methanol and water as the solvents following standard protocols. Cytotoxicity was assessed using MTT assay, trypan blue dye exclusion, AO/EB staining and fluorescence microscopical analysis and DNA fragmentation analysis. Results: Ethanol extract has shown significant cytotoxicity (P<0.001) to fibrosarcoma and least toxicity to normal human lymphocytes when compared to the controls. Conclusions: This study shows that O. marjorana ethanol extract has anticancer potentials and can be explored further for active component isolation, identification and characterization.
In vitro produced glycoalkaloids from Solanum nigrum L. and evaluation of their potential role as antibilharziasis
Objective: To evaluate the anti schistosomiasis activity of the bioactive formed glycoalkaloids from Solanum nigrum L. (family: Solanaceae) (S. nigrum) to control one of the most prevalent parasitic tropical diseases. Me...
Implications of ischemia modifid albumin levels in hypertension
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Intestinal helminths in immigrants in Naples (Italy): a comparison between two different diagnostic techniques
Objective: To compare two different methods for detection of intestinal parasitic in immigrants from high risk geographic areas for intestinal parasitic diseases. Methods: A total of 307 stool specimens were analysed by...
Phytochemical screening and antimalarial activity of some plants traditionally used in Indonesia
Objective: To evaluate ethanolic extracts of phytochemical screening, in vitro and in vivo antiplasmodial activities of 15 plants used as antimalarial in Sei Kepayang, North Sumatra. Methods: Extraction was done through...
Pharmacognostic and clinical aspects of Cydonia oblonga: A review
Cydonia oblonga Miller (C. oblonga) is considered as an important medicinal plant throughout the world. It is native to Mediterranean region and Central Asia having a long term history of medicinal and ethnobotanical use...