Evaluation of the Effect of Hydroalcoholic Extract of Psidium Guajava Linn. (Myrtaceae) Leaf with Synovium-derived Stem Cells and Platelet Rich Plasma (PRP) on Induced Osteoarthritis of the Knee in Male Rats
Journal Title: Majallah-i jarrāḥī-i ustukhvān va mafāṣil-i Īrān - Year 2017, Vol 15, Issue 2
Abstract
Background: The available synthetic drugs for treatment of Osteoarthritis (OA), a degenerative arthritis, have serious side effects and low efficacy. Therefore, using herbal medicines, with mesenchymal stem cells, as an important component of alternative and complementary medicine, have an effective role in the treatment of diseases. Psidium guajava leaves are used as antioxidant, anti-inflammatory and antinociceptive/analgesic drugs. The present study aimed to evaluate the effect of injection of the hydroalcoholic extract of Psidium Guajava leaf with stem cells into the articular cartilage of rats’ knees. Methods: Ninety male rats were chosen and collagenase type II was prepared for an intra-articular knee injection, for induction of OA. Then, the rats were divided into nine treatment groups (10 rats in each group): (a) Sham, (b) Control, (c) Hyaluronic Acid intra-articular injection, (d) Stem Cells intra-articular injection, (e) PRP injection, (f): Hydroalcoholic extract injection’ Hydroalcoholic extract injection (PGL), (g) PGL with PRP injection, (h) PGL with stem cells injection, and (i) PGL with stem cells and PRP injection. Aer 5 months, the results were assessed by a radiologist and histopathologist. Results: Radiological and histopathological findings showed higher improvement of the articular cartilage in groups with PGL, stem cells and PRP groups, compared with the control group (P<0.05). Conclusions: Psidium guajava leaves, with polyphenol compounds, can be suggested as an effective complementary and alternative treatment for knee OA.
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