Evaluation of the efficacy of the utilization of the imipramine for patients with allergic rhinitis
Journal Title: Archives of Otolaryngology and Rhinology - Year 2017, Vol 3, Issue 3
Abstract
Background: allergic rhinitis is an inflammatory process of the upper respiratory tract with a continuous symptom that last for hour or more with symptom affect patient’s work and quality of life. Methodology: a randomized controlled trial in which we enrolled 284 patients with allergic rhinitis for periods longer than 4 days/week and for more than 4 consecutive weeks divided into two groups. Group A (n=142) received Imipramine 75 mg/day for 90 days .Group B (n=142), the control group, received desloratadine 5 mg / day for 90 days. Results: The mean visual analogue score nasal symptoms intensity (sneezing, Nasal obstruction, watery rhinorrhea and itchy nose) showed a statistically significantly improvement in group A (treated with Imipramine) compared with group B (treated with desloratadine) after the same treatment period. Conclusion: Imipramine could be used in treatment patients with allergic rhinitis as it is effective as an antihistaminic besides its main action in reliving psychosocial stresses.
Authors and Affiliations
El Hennawi Diaa El Din, Ahmed Mohamed Rifaat, Madian Yasser T, El-Tabbakh Mohammed T, Ibrahim Ibrahim Hassan
Keywords
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- EP ID EP352159
- DOI 10.17352/2455-1759.000052
- Views 85
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