EVALUATION OF THE EXTRACTS OF LEUCAS ASPERA ON BIOCHEMICAL PROFILES IN EXPERIMENTAL MODEL OF DIABETES MELLITUS (TYPE- I) IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The study was conducted to evaluate the effect of Leucas aspera leaves on experimental diabetes mellitus (type I) in rats in terms of alterations in biochemical profiles. Thirty rats were randomly divided into six groups of 5 rats in each. Group-I were fed on basal diet without any treatment, group-II induced diabetic models (type-I) (Alloxan monohydrate dissolved in sterile normal saline (150 mg/kgBW, ip)), group-III, IV, V and VI were induced diabetics and treated with extract of Leucas aspera (30,100,150 and 300mg/kg BW respectively, PO) twice daily in the morning and evening post prandially for thirty days respectively. The blood samples were collected on day 0, 10, 20 and 30 and were used for the analysis of biochemical profiles. The blood glucose (mg%) were consistently increased significantly (P<0.01) in groups II,III, IV V and VI till day 20 while in groups V and VI there was a significant (P<0.01) decline in the values on day 30. There was found to have profound effect in lowering the blood glucose levels in dose dependent manner. The study revealed that experimental diabetes mellitus (type-I) induced patho-biochemical changes were ameliorated more effectively by ethanolic extract of Leucas aspera in dose dependent manner.
Authors and Affiliations
T. Tukaram , Parvati C. V. , Venkat Rao, Prakash Patil , Sreenivas Rao
Keywords
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