EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE ALCOHOLIC EXTRACTS OF RUTA GRAVEOLENS LEAVES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 11
Abstract
Objective: The present study was undertaken to evaluate the immunomodulatory activity of the alcoholic extracts of Ruta graveolens leaves in vivo.Methods: Immunomodulatory activity was determined by neutrophil adhesion test, phagocytic activity, haemagglutinating antibody (HA) titre and delayed-type hypersensitivity (DTH) response.Results: Oral administration of the extracts (50, 100, 150 and 200 mg/kg bw, p. o) evoked a significant (**P<0.01) increased in percent of neutrophil adhesion to nylon fibers. Both the extracts were also increased the antibody titre in a dose-dependent manner. Oral administration of both the compound significantly (**P<0.01) potentiated delayed type hypersensitivity reaction induced by sheep red blood cells and response towards phagocytosis in carbon clearance assay. In this study indicated that leaves extracts possesses potent immune-modulatory activity in a concentration-dependent manner. The response was statistically significant when compared with the control (*P<0.05, **P<0.01).Conclusion: The study stated that Ruta graveolens leaves extracts showed a significant stimulation of the cell-mediated immunity as well as humoral immunity. Further investigations are required to determine its active constituents and also its mechanism of action.
Authors and Affiliations
Pinkee Pandey, Archana Mehta, Subhadip Hajra
Keywords
Related Articles
- EP ID EP575930
- DOI 10.22159/ijpps.2016v8i11.15531
- Views 65
- Downloads 0
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