Evaluation of the Protective Effects of Constituents of an Ayurveda Herbal Eye Drop Preparation in Albino Rabbits
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Background: Benzalkonium chloride (BAK) is a common preservative used in eye drops and it is known to be corrosive for the eyes. The present study intended to evaluate the possible protective effect of the herbal contents of Ayurvedic eye drops with BAK as the preservative in the eyes of 24 New Zealand, white albino rabbits. Method: The animals were allocated to an experimental (n = 18) and control group (n = 6). The rabbits in the experimental group were given the test substance daily for 28 days while the control group was kept in the same conditions without any treatment. Irritation of the eye, body weight, and mortality rate were observed on Day 7, 14, 21 and 28 after the commencement of the experiment. The animals were sacrificed after 28 days. Hematological and biochemical tests were conducted from the blood samples collected before the sacrifice. Microscopic examination of the tissue and organs were conducted after the sacrifice. Student’s t-test was conducted to compare the data of the experimental and control group. Result: There was no evidence of irritation or any pathology in both the experimental and control animals. Ayurveda eye-drops appear to reduce the irritating effects of BAK. Conclusion: The herbal constituents are individually irritating to the eye in combination they did not result in irritation.
Authors and Affiliations
Sadhna Verma, Nilkamal Singh, Shirley Telles, Acharya Balkrishna
Keywords
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- EP ID EP542320
- DOI 10.21276/ijmrp.2017.3.1.032
- Views 43
- Downloads 0
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