Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 1
Abstract
Introduction: Colorectal Carcinoma (CRC) is the third most commonly diagnosed cancer in males. Stem Cells (SC) may be involved in tumour growth, including colon cancer. Aldehyde Dehydrogenase 1 (ALDH1) is a detoxifying enzyme that might modulate SC proliferation. Aims: To evaluate the immunohistochemical expression of ALDH1 as stem cell marker in the pathogenesis of colorectal carcinoma. Materials and Methods: This retrospective study included 71 colorectal specimens (49 colorectal carcinoma, 13 adenoma and 9 normal cases) that were collected from Pathology Department, Faculty of Medicine, Menoufia University during the period from 2011 to 2015. All cases were stained by ALDH 1 antibody. Survival data were available for 31cases. Results: There was a statistical significant association between epithelial positivity of ALDH1 and younger age (p=0.003), right sided tumour (p=0.038), presence of lymph node invasion (p= 0.04), ulcerating gross picture (p=0.01) and presence of vascular invasion (p=0.05). Moreover, there was statistical significant association between stromal positivity of ALDH1 and smaller tumour size (p=0.03) and inverse association between stromal expression of ALDH1 and grade of tumour (p=0.000) and perineural invasion (p= 0.05). Furthermore, there was an inverse significant relation between CD44 and ALDH1 expression (p=0.001). Univariate recurrence free survival analysis revealed the bad prognostic impact of high grade (p=0.03) and female sex (p=0.02) on patient outcome. Conclusion: Epithelial expression of ALDH1 might be associated with poor prognosis while its stromal expression might be associated with good prognosis.
Authors and Affiliations
Nanis Shawky Holah, Hayam Abd-El-Samie Aiad, Nancy Yousif Asaad, Enas Abobakr Elkhouly, Ayat Gamal Lasheen
Keywords
Related Articles
- EP ID EP327094
- DOI -
- Views 135
- Downloads 0
Mental Health and Old Age: A Qualitative Study in Iranian Population
Introduction: Health, which usually declines with age, is one of the determinants of quality of life. Mental health disorder is one of the most common health-threatening problems of older age. Aim: The present qualitativ...
A Comparative Study on Quality of Life between Ileal Conduit Urinary Diversion and Orthotopic Neobladder Reconstruction after Radical Cystectomy
ABSTRACT Introduction: Ileal Conduit (IC) urinary diversion and Orthotopic Neo Bladder (ONB) reconstruction may have an effect on the Health-Related Quality of Life (HRQoL) of patients. Aim: To compare the quality of lif...
Treatment of Periradicular Bone Defect by Periosteal Pedicle Graft as a Barrier Membrane and Demineralized Freeze-Dried Bone Allograft
The purpose of this case report is to describe the usefulness of Periosteal Pedicle Graft (PPG) as a barrier membrane and Demineralized Freeze-Dried Bone Allograft (DFDBA) for bone regeneration in periradicular bone defe...
Metaplastic Carcinoma Breast: A Clinical Analysis of Nine Cases
Metaplastic Breast Carcinoma (MBC) is a rare heterogeneous group of primary breast malignancies with different subgroups; exhibits a variety of histopathologic patterns and appears to be both epithelial and mesenchymal i...
Pure Primary Extragonadal Retroperitoneal Yolk Sac Tumour in a Young Child: A Case Report
Germ Cell Tumours (GCTs) in children are uncommon, constituting approximately only 3% of all malignancies in children younger than 15 years of age. Primary extragonadal GCTs constitute only 1-5% of all GCTs and a retrope...