Evaluation of the Role of Dermatoglyphics, Oral Micronuclei and ABO Blood Grouping in Determining Type 2 Diabetes-A Multi-Parameter Approach
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Diabetes mellitus type-2 affecting around 12% of Indian population is a multifactorial metabolic disease with several complications warranting high concern for effective prevention and control measures. Aim: To evaluate the role of dermatoglyphics, oral micronuclei and ABO blood grouping in determining Type 2 diabetes. Materials and Methods: A total of 44 diabetic patient and 45 age and sex matched healthy controls were selected. Palmar prints, oral cytosmears and blood samples were collected from both groups. Fingerprints and ATD angle were assessed from the palmar prints. Oral smears obtained were stained using Papanicolaou stain and assessed for micronuclei frequency. About 1 mL of blood sample obtained by venepuncture method was subjected to ABO blood grouping. Dermatoglyphic findings were expressed as Mean±SD. Independent sample t-test was used for comparison of ATD angle and oral micronuclei frequency in both groups. Chi-square test was used for testing the association of blood grouping to diabetes mellitus. Results: On fingerprint analysis, ulnar loops were found to be more in diabetics with reduced number of whorls. There was slight increase in arches as well except in left hand of diabetic females. Statistically significant results were obtained with ATD angle and oral micronuclei with diabetics having higher values. There was no significant association found between diabetes and blood groups. Conclusion: A panel of biomarkers which are simple, economical and rapid improves the screening surveillance of diabetes and act as an additional diagnostic tool. Micronuclei and ATD angle in the present study exhibited significant results and might be possible components of the panel. Mass screening of high risk individuals at community level can be achieved using a kit with the biomarkers. To validate the relation of blood groups to diabetes further evaluation over larger population is needed.
Authors and Affiliations
Ratna Kumari VN Tarigoppula, Manasa Syamala, Ahmed Mujib Bangalore Raheem, Shruthi K Patil
Keywords
Related Articles
- EP ID EP529783
- DOI 10.7860/JCDR/2018/35920.12119
- Views 54
- Downloads 0
Melanoacanthoma of Pinna-Treated with Skin Grafting: A Case Report
ABSTRACT Melanoacanthoma is a very rare cutaneous lesion and it is considered to be a benign neoplasm, which is composed of large dendritic melanocytes and epidermal keratinocytes. Very few case reports of melanoacanthom...
Single-Dose Oral Dexamethasone Compared with Three Day Course of Oral Prednisolone in Children with Moderate Exacerbation of Asthma-A Pilot Double-Blinded Randomised Controlled Trial
Abstract Introduction: Corticosteroids are the mainstay of treatment for a child with acute exacerbation of asthma. Though, several guidelines suggest use of prednisolone for few days, recently single dose dexamethasone...
Is Preoperative Anthropometric Data Assessment Reliable Indicator for Estimating Femoral Tunnel Length in Anterior Cruciate Ligament Reconstruction?
ABSTRACT Introduction: Correct length of the femoral tunnel is required for adequate length of graft inside the femoral canal. Length of femoral tunnel depends on mass, height, dimensions of lateral femoral condyle and a...
Clarification of Quantitative Intraoral Circumstances with the Community Periodontal Index of Treatment Needs Data using Covariance Structure Analysis
ABSTRACT Introduction: Although the severity of periodontal disease is evaluated by various indices, the susceptibility is different among tooth types in the same dentition. Community Periodontal Index of Treatment Needs...
Conservative Approach in a Patient with Cervical Intraepithelial Neoplasia Type-3 in Pregnancy: Impact on Disease Progression and Pregnancy Outcome
ABSTRACT Treatment strategy of Cervical Intraepithelial Neoplasia-3 (CIN 3) in background of High Grade Squamous Intraepithelial Lesion (HSIL) is very different amongst the pregnant and non-pregnant women. This case repo...