Evaluation of Thrombocytopenia in a Tertiary Care Centre
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 4
Abstract
Abstract: Thrombocytopenia is a common clinical problem with many etiological causes. This may result due to decreased platelet production, increased destruction of platelets and differentiation in distribution of platelets. Although transient bone marrow suppression and marrow infiltration by malignancies are important causes, certain non-malignant condition such as infections and drugs are equally important as their treatment is simple and complete recovery is the rule. Detection of the exact etiology is important for specific treatment and prognostication. In this retrospective study, a total of 120 patients with thrombocytopenia from different departments of hospital were included, graded and evaluated for etiology. 66 patients(55%) were female and 54 patients(45%) were male. The patients’ age ranged from 6 months to 80 years. 35 cases(29%) showed Grade 1 thrombocytopenia, 17 cases(14%) Grade 2, 24 cases(20%) Grade 3 and 44 cases(37%) had counts less than 25000/cu.mm, i.e Grade 4 thrombocytopenia. Infections, leukemia, and immune thrombocytopenia represented majority of the cases, and the less frequent causes of thrombocytopenia were found to be drugs, chronic liver disease, multiple myeloma and others. The study concludes that thrombocytopenia has a wide spectrum of causes which can be diagnosed by detailed history and peripheral smear examination supported by bone marrow examination and other relevant investigations. The reasons of thrombocytopenia may differ according to geographic distribution and level of health center. In developing countries, high rate of infections was found to be the main reason for thrombocytopenia followed by malignant diseases encountered in a tertiary care hospital. Keywords: Thrombocytopenia, Bone marrow suppression, Bone marrow infiltration, Non-malignant conditions
Authors and Affiliations
Dr. Anjan Kumar Das, Dr. Sambit Dasgupta, Dr. Amrita Sarkar
Keywords
Related Articles
- EP ID EP370959
- DOI -
- Views 40
- Downloads 0
Serum gastrin level estimation, is it a prognostic indicator in operated carcinoma stomach patients?
Abstract: Inspite of substantial geographic variation, gastric carcinoma still continues to be one of the most common tumours worldwide. Variants of tumour markers have been and are being established for diagnosis of gas...
Working Memory Limit of Young Male Wistar Rats in Return T Maze Delayed Spontaneous Task Alternation
In rat maze training tasks, the working memory is a short term memory of remembering a previously visited area or reward to solve the task which lasts for a single trial. 10 young (age = 4 months) male Wistar rats were s...
Dyslipidemia – Could It Be A Reliable Prognostic Factor In Cirrhosis Of Liver? An Approach to Find Out By A Cross Sectional Analytical Study in a Tertiary Care Hospital
Abstract: Cirrhosis is the end stage consequence of fibrosis of hepatic parenchyma, resulting in nodule formation that may lead to altered hepatic function and blood flow. There are a wide variety of tests to evaluate th...
A Rare Cause of Secondary Postpartum Haemorrhage: Hyperactive Placental Site
A 26 years old woman para3 living3 presented to gynae emergency in haemorrhagic shock (secondary postpartum haemorrhage) with severe anaemia on post natal day 10 of normal vaginal delivery at home. There was history of p...
Assessment of Allergens responsible for Allergic diseases in Central Maharashtra, India by using Skin Prick Test
Abstract: Allergens play a major role in the pathogenesis of respiratory allergic diseases, particularly asthma and rhinitis. History taking and clinical examination are very important for determining allergy. Skin prick...