Evaluation of thromboprophylaxis in bad obstetric history patients with elevated antiphospholipid antibodies
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 5
Abstract
Objectives: To find the effect of thromboprophylaxis on pregnancy outcome in patients with elevated antiphospholipid antibody. To compare efficiency of aspirin alone and aspirin plus low molecular weight heparin (LMWH) in pregnancy outcome in patients with elevated antiphospholipid antibody. Methods: The present study, prospective randomised control study conducted at kasturba medical college Manipal, Karnataka from nov.2000-nov.2002. During the study, patients with 2 or more consecutive abortions, 1 or more intrauterine deaths and 1or more neonatal deaths were included in the study. Out of 111 patients with bad obstetric history who underwent anticardiolipin antibody assay by enzyme immune and lupus anticoagulant assay by activated partial thromboplastintime (APTT), 57 had elevated antiphospholipid antibodies. Out of these 57 patients 37 received aspirin and 20 patients received aspirin with low molecular weight heparin. Results: Elevated antiphospholipid antibodies were seen in 51.3% of bad obstetric history patients. Antiphospholipid were associated with 1st trimester loss in 70.2% patients 5.3% had 2nd trimester loss. Both 1st and 2nd trimester loss was seen in 3.5%, 14% IUDS and 7% had NND. The live birth rate was 65.8% with thromboprophylaxis and 6.5% without thromboprophylaxis which is statistically significant. Live birth rate with aspirin alone was 52.4% and with aspirin plus LMWH was 82.4% which is statistically significant. 56.3% live birth seen in patients with thromboprophylaxis in pre and post conception period. 72.7% live birth in patients with thromboprophylaxis in post conception period which is not statistically significant. Conclusion: Thromboprophylaxis with aspirin plus LMWH leads to significant higher rate of live births than aspirin alone.
Authors and Affiliations
Anjanadevi Santpure, Prasad Bhanap
Keywords
Related Articles
- EP ID EP191955
- DOI -
- Views 112
- Downloads 0
Analysis of drug consumption in rural health center of tertiary care teaching hospital, Kancheepuram district, Tamil Nadu
Introduction: With advanced medical care and drugs, consumption of drug cost from budget allocation is high. It has been proved that control measures in monitoring drug consumption have resulted in 20% saving in cost uti...
Use of low dose intravenous ketamine for paediatric anaesthesia
Ketamine is 2-(2-chlorophenyl)-2 methylamino cyclohexanone hydrochloride- a phencyclidine derivative. Onset of anesthesia is rapid, but recovery from a bolus dose is slower than for propofol and thiopentone. Ketamine, un...
Giant cell tumour of soft tissue arising from intra muscular region of thigh - A rare case report
Giant cell tumour arising from soft tissue is a rare condition, which is of low malignant potential resembling giant cell tumour of bone histologically, Also known as osteoclastoma of soft tissue. We report a case of 29...
Left sided Gastrochisis with spinal and limb deformities: a case report
Gastroschisis represents a herniation of abdominal contents through a paramedian full-thickness abdominal fusion defect. The abdominal herniation is usually to the right of the umbilical cord. Very few cases of left side...
Uteroperitoneal fistula – a rare cause of failure of sterilization
Failed sterilization is uncommon event. Recanalization leading to failure is commonly understood reason for this. Here we present to you a rare case of uteroperitoneal fistula leading to so called sterilization failure.