Evaluation of thyroid function in patients of chronic kidney disease
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Background: Chronic Kidney Disease (CKD) is abnormal kidney function with low GFR (<60 ml/min/1.73m2) for 3 or more months. Prevalence of CKD in India is 17.2% and over 2 million people world wide receive dialysis treatment. Kidney plays an important role in the metabolism and excretion of thyroid hormones. CKD is known to affect the pituitary thyroid axis and the peripheral metabolism of thyroid hormones. Euthyroid state, hypothyroidism andhyperthyroidism have all been reported in previous studies. Considering the variation of thyroid function tests in patients with CKD in previous studies, the present study is undertaken to evaluate thyroid function and to establish a correlation if any between thyroid dysfunction and severity of CKD. Materials and Methods: 50 patients of established CKD in the age group of 30-60 yrs without thyroid disease were included in study group and 50 age matched healthy subjects formed the control group. Thyroid function is evaluated in both groups by measuring Total serum T4, serumT3 and serum Thyroid stimulating Hormone (TSH). Serum creatinine and blood urea are measured in both the study and control groups. Statistical analysis was done by student t test by comparing mean serum values. Results: In study group mean serum creatinine and mean blood urea level are higher than the mean blood urea level in control group, which is statistically significant (p<0.001). Mean value of serum T3 level was significantly less in study group (0.692±0.37) when compared to control group (1.19±0.82) (p <0.001). Mean value of serum T4 level was significantly low in study group (5.4±2.6) as compared to control group (7.86±1.94) (p<0.0001) Mean serum TSH level was significantly higher in study group (4.76±2.99) when compared to the control group (3.12±1.77) (p<0.001)).Patients with high TSH levels above normal range (0.34 to 5.6 μIU/L ) were 17. The prevalence of subclinical hypothyroidism is calculated as 34 % in study group. In control group only two subjects were having more TSH levels than normal range. So prevalence of subclinical hypothyroidism is 4 %. Conclusions: Mean serum T3and T4 levels are low and mean serum TSH levels are high in study group compared to control group suggesting association of subclinical hypothyroidism in cases of CKD.
Authors and Affiliations
V Ratnakumari, P Kiranmai
Keywords
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