Evaluation of Thyroid Hormones Level in Patients with Type 2 Diabetes Mellitus as Compared to Normal Individuals in Nepal
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 1
Abstract
Objective: Diabetes mellitus and thyroid disorders are two of the most common endocrine disorders. Studying the levels of thyroid hormones in patients with type 2 diabetes mellitus can aid in the diagnosis of various thyroid related disorders. The aim of this study was to evaluate thyroid hormones (free tri-iodothyronine [FT3] and, free thyroxine [FT4]) and thyroid stimulating hormone (TSH) in patients with type 2 diabetes mellitus as compared to normal individuals. Methods: The study was conducted at Norvic International Hospital, Kathmandu, Nepal. The study included thirty patients with type 2 diabetes mellitus attending the Inpatient and Outpatient departments. Serum levels of FT4, FT3 and TSH were estimated as part of a thyroid hormone assay. Glycosylated hemoglobin (HbA1c) and random plasma glucose were estimated to test diabetes. Results: Statistically significant differences were observed in the mean FT3 activity of normal individuals (4.44 ± 0.82) and patients with type 2 diabetes mellitus (3.37 ± 1.14; P =0.000). Statistically significant differences were also observed in the mean FT4 activity of normal individuals (1.45 ± 0.39) and patients with type 2 diabetes mellitus (1.1± 0.335; P=0.002). Statistical differences in the mean TSH activity were also observed between normal individuals (3.56 ± 2.50) and patients with type 2 diabetes mellitus (5.52 ± 2.41; P=0.003). A positive correlation between TSH and HBA1c (0.397) and a negative correlation between FT3 and HbA1c (-0.508) was found. Conclusions: Thyroid hormone levels in patients with type 2 diabetes mellitus are perturbed with an increase in TSH and decrease in FT3 and FT4. Therefore this study suggests hypothyroidism in patients with type 2 diabetes mellitus.
Authors and Affiliations
Arun Acharya
Keywords
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