Evaluation of Topical Monotherapy for Early Primary Open Angle Glaucoma Patient
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 3
Abstract
<strong>Background</strong>: primary open-angle glaucoma is asymptomatic optic neuropathic ocular disease characterized by enlarging optic disc cupping and visual field loss. World Health Organization estimated in a systemic review that glaucoma is the second commonest cause of blindness worldwide and topical ocular hypotensive medication was effective in delaying the onset of open angle glaucoma in individuals with elevated ocular pressure.<strong> Aim of the work</strong>: the study aimed to evaluate the safety and pressure-lowering efficacy of travoprost (0.004%) compared to timolol 0.5% and compared to brimonidine tartrate 0.2% as monotherapy in patients with primary open-angle glaucoma <strong>Patients and methods:</strong> patients were randomized to 3 groups, the first group was received travoprost 0.004%, the second group was received timolol 0.5% and the last group was received brimonidine tartrate 0.2%. This study was carried out in Menoufia University during the period from January 2016 to January 2017. <strong>Result: </strong>this study included 45 patients who were randomized to 3 groups, the first group received prostaglandins analogue, the second group received beta blockers and the last group received alpha agonists. Collected data indicated that the intraocular pressure–lowering efficacy of travoprost was significantly better compared to timolol and brimonidine at months 3, 6, 9, 12 (P <.001). <strong>Conclusion:</strong> using primary monotherapy, the intraocular pressure–lowering efficacy of travoprost 0.004% was superior to timolol 5% and superior to brimonidine tartrate 0.2% in patients with primary open-angle glaucoma. Travoprost, timolol and brimonidine reduced intraocular pressure effectively in primary open angle glaucoma.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP583491
- DOI 10.12816/0043477
- Views 115
- Downloads 0
Prophylactic Oral Nifedipine to Reduce Preterm Delivery: A Randomized Controlled Trial in Women at High Risk
<span>Objective: </span><span>to evaluate </span><span>the efficacy of prophylactic nifedipine versus placebo in reducing spontaneous preterm delivery in asymptomatic women at high risk for preterm delivery.<br /> </span...
Wound Infection after Laparoscopic Cholecystectomy
<strong>Background: </strong>Surgeons are regularly not involved in the post discharge care of patients after uncomplicated laparoscopic cholecystectomy. The purpose of the current study was to document the symptomatic r...
Surgical Management of Patients with Infective Endocarditis: A Systematic Review
<strong>Introduction: </strong>Replacement of the heart valves has been spread recently with wide variety of types and surgical techniques. There is, however, no consensus regarding the best type and/or techniques of the...
Levonorgestrel Releasing IUS (Metraplant E) in the Management of Copper IUD Related Heavy Painful Menstrual Loss
<span>Background: </span><span>the LNG-IUD was first introduced in Finland in 1990 and is currently marketed in most European countries and in the US since 2000</span><span>. </span><span>The Levonorgestrel IUD is approv...
Timing of Renal Replacement Therapy and its impact on the Outcome of Acute Kidney Injury Patients
<strong>Background: </strong>Previous studies using Acute Kidney Injury Network (AKIN)/RIFLE criteria to classify early initiation of renal replacement therapy (RRT) have defined it as the therapy started in less severe...