Evaluation of Total Intravenous Anesthesia by Ketamine-Xylazine Constant Rate Infusion in Dogs: A Novel Preliminary Dose Study
Journal Title: Veterinary Medicine – Open Journal - Year 2017, Vol 2, Issue 2
Abstract
Background and Aims: The use of ketamine-xylazine for total intravenous anesthesia (TIVA) by constant rate infusion (CRI) has not been well-documented in literature. The present study aimed to define the optimal dosage of ketamine-xylazine for TIVA in dogs and its effects on physiological body parameters. Materials and Methods: Twenty mongrel dogs were randomly assigned to four treatment protocols (n=5): A (0.5 mg kg-1, ketamine+ 0.25 mg kg-1, xylazine and 0.6 mg kg-1 h-1, ketamine+0.3 mg kg-1 h-1, xylazine ), B (5 mg kg-1, ketamine+0.5 mg kg-1, xylazine and 10 mg kg-1 h-1, ketamine+1 mg kg-1 h-1, xylazine), C (2 mg kg-1, ketamine+0.5 mg kg-1 xylazine and 5 mg kg-1 h-1, ketamine+0.5 mg kg-1 h-1 xylazine), and D (2 mg kg-1 ketamine+1 mg kg-1 xylazine and 10 mg kg-1 h-1, ketamine+1 mg kg-1 h-1 xylazine) for induction and maintenance of anesthesia, respectively. Results: The anesthesia was deep in protocols B, C, and D (pedal reflex of grade=0), but light in the protocol A (pedal reflex of grade=3). Animals in both protocols B and C showed paddling and tonic clonic convulsions. All the protocols recorded a non-significant increase in the body temperature but; a significant decrease in the respiratory rate. There was a nonsignificant decrease in the heart rate in protocols A and C; while a non-significant increase was recorded in protocols B and D. Conclusion: The protocol D could be considered as the optimal dosage of ketamine-xylazine for TIVA by CRI in dogs, with minimal effects on vital body parameters, for extended surgical interventions.
Authors and Affiliations
Ahmed Ibrahim
Keywords
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- EP ID EP545158
- DOI 10.17140/VMOJ-2-114
- Views 166
- Downloads 0
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Evaluation of Total Intravenous Anesthesia by Ketamine-Xylazine Constant Rate Infusion in Dogs: A Novel Preliminary Dose Study
Background and Aims: The use of ketamine-xylazine for total intravenous anesthesia (TIVA) by constant rate infusion (CRI) has not been well-documented in literature. The present study aimed to define the optimal dosage o...