Evaluation of usefulness of modern echocardiographic techniques using speckle tracking echocardiography, in experimental laboratory conditions, on example model of acute ischemic disease in mice
Journal Title: Annales Academiae Medicae Silesiensis - Year 2018, Vol 72, Issue
Abstract
In recent years, mice have become the most commonly used laboratory animals in preclinical studies. With the increase in their use also in the study of the cardiovascular system (in heart muscle cell regenerating therapies after a heart attack, heart failure or assessing the cardiotoxicity of drugs), there was a need to develop accurate methods for assessing cardiac function, which could reliably determine the efficacy and safety of the studied treatments. The transfer of speckle tracking technology to echocardiography experimental conditions, allows a more reliable and credible assessment of the effectiveness of the studied treatments. Measurements of regional deformation of the heart obtained by this method are much more sensitive and specific than the parameters of classical echocardiography. Speckle tracking echocardiography (STE) seems to be a very attractive method but it is not devoid of drawbacks and limitations. Analysis of the 2D STE technique is very sensitive to artifacts, blurring the boundaries that prevent proper endocarditis tracking speckle. Therefore, obtaining reproducible images of good quality is still a major challenge, particularly in experimental echocardiography. In the available literature, the technical and practical aspects of this study are often overlooked or described very enigmatically, and often it is those aspects that are essential to achieve satisfactory images. Therefore, the aim of this study is to evaluate the usefulness of both modern echocardiographic techniques in experimental conditions in the laboratory and to describe the technical and practical issues of conducting echocardiography in mice.
Authors and Affiliations
Marcin A. Garbacz, Tomasz Niklewski, Joanna Śliwka, Maciej Domagała, Marcin Kaczmarczyk, Mateusz Garbacz, Karol Froń, Michał Zembala, Marian Zembala
Keywords
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- DOI 10.18794/aams/78691
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