Evaluation of Vitamin D Deficiency in Patients with Chronic Liver Disease and Its Clinical Significance
Journal Title: International Journal of Nutrition - Year 2016, Vol 2, Issue 2
Abstract
Introduction: Vitamin D deficiency has been reported highly prevalent in Chronic liver disease (CLD) and there is an emerging interest to explore the relationship of vitamin D deficiency and severity of various types of CLD. Aim: To evaluate vitamin D level in patients with various type of CLD and clinical significance of its deficiency. Materials and Methods: Serum vitamin D levels were measured by ELFA in 100 patients (91 male and 9 female) suffering from CLD. The degree of liver dysfunction was estimated by Child Pugh criteria and Model for End stage Liver Disease (MELD) score. Results: Prevalence of vitamin D deficiency and insufficiency were 43% and 42% respectively among CLD patients. Low levels of vitamin D were associated with leucopenia or leucocytosis indicating increased risk of infection. On Linear regression vitamin D level showed significant negative correlation with Child Pugh score (r = – 0.7382, p<0.0001) and MELD score (r = – 0.6673, p<0.0001). Our study shows low vitamin D level was associated with poor outcome (mean vitamin D level 10.38 ± 2.35 who died vs 23.14 ± 6.68 who survived and discharged). Conclusion: CLD is associated with a significantly low level of vitamin D which was independent to patient’s gender, BMI, residence and education level. The lower level of vitamin D is associated with severity of CLD, mortality and increased risk for infections. Awareness of serum vitamin D level in patients with CLD is important to improve outcome.
Authors and Affiliations
Bal Kishan Gupta, Makkhan Lal Saini, Hardeva Ram Nehara, Shyam Lal Meena, Meghraj Saini, Jigyasa Gupta
Keywords
Related Articles
- EP ID EP319735
- DOI 10.14302/issn.2379-7835.ijn-16-1381
- Views 123
- Downloads 0
Influence of Chemical Refining Processes on the Total Phenolics and Antioxidant Activity of Sunflower Oil
The raw sunflower oil (SFO) has an undesirable flavour and odour. Therefore, to make it suitable for human consumption, the oil has to undergo a number of refining processes such as degumming, neutralization, bleaching a...
Organic or Psychiatric Disease? A Misdiagnosed Superior Mesenteric Artery Syndrome
Superior mesenteric artery syndrome 1, 2, 3, 4 is a rare disorder characterised by a compression of the duodenum because of the reduced angle between the aorta and superior mesenteric artery. The disease is clinically ch...
Docosahexaenoic Acid Supplementation is Not Anti- Inflammatory in Adipose Tissue of Healthy Obese Postmenopausal Women
Adipose tissue inflammation is associated with obesity comorbidities. Reducing such inflammation may ameliorate these comorbidities. n-3 fatty acids have been reported to have anti-inflammatory properties in obesity, whi...
Age Variation in Bitter Taste Perception in Relation to the Tas2r38 Taste Receptor Phenotype
Objectives Taste sensitivity is an important determinant of food choice and differs between children and adults. This difference is probably due to several factors that constitute an individual’s phenotype. The aim of th...
Reversal of Obesity: The Quest for the Optimum Dietary Regimen
A new approach to weight loss and weight loss maintenance is urgently needed, with the global epidemic of obesity leading to ever higher levels of chronic disease. This new approach should be cheap and simple, it should...