EVALUATION OF “YAK001” FOR SAFETY PROFILE: ACUTE ORAL TOXICITY STUDY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 8
Abstract
This study determines acute toxicity of a coded drug “YAK001” an oral formulation prepared with suspension of test drug using gum acacia in rats. It was assessed for single dose acute toxicity by employing OECD guidelines 425 using AOT software. The dosed (up down as per requirement) rats were observed for 14 days, for general appearance, cage side behavior including increased or decreasing motor activity, convulsions, straub’s reaction, catatonia, muscle spasm, spasticity, ophisthotonus, hyperesthesia, muscle relaxation, anaesthesia, arching and rolling, lacrimation, salivation, diarrhea, writhing movement, mode of respiration and changes in skin color etc., with mortality and autopsy finding in case of dead animal. The test drug did not produce any mortality up to the dose of 2000 mg/kg per oral which is equivalent to 22.4g total dose for a human being weighing 70 kg man.
Authors and Affiliations
Hari K. R. , Ankur Patel, Ravi Mundugaru, Ravishankar B.
Keywords
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- EP ID EP106420
- DOI 10.7897/2230-8407.068110
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