EVALUATION ON LIPID PEROXIDATION AND ANTIPROLIFERATIVE ACTIVITIES OF RAPHANUS SATIVUS L
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 5, Issue 6
Abstract
Raphanus sativus L. is a most commonly used vegetable belonging to the family Cruciferae. In the present study, the plant material was procured and processed for cold extraction procedure using 70% ethanol. The extract was screened for the qualitative phytochemical analysis, in vitro lipid peroxidation inhibition and antiproliferative activites. From the results, Raphanus sativus L. revealed potent lipid peroxidation inhibition with an IC50 value 281.9 µg/mL compared to standard ascorbic acid and BHT. Further, MTT assay was used to measure cell proliferation against NIH-3T3, DLA and MCF7 cell lines and the significant results were recorded in the plant extract with an IC50 value of 415.4 µg/mL, 423.2 µg/mL and 703.5 µg/mL respectively.
Authors and Affiliations
Jamuna K. S. | Molecular Biomedicine Laboratory, PG Dept. of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shimoga - 577203, Karnataka, India, Suma M. S. | Molecular Biomedicine Laboratory, PG Dept. of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shimoga - 577203, Karnataka, India, Ramesh C. K| Molecular Biomedicine Laboratory, PG Dept. of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shimoga - 577203, Karnataka, India, Riaz Mahmood| Postgraduate Department of Studies and Research in Biotechnology and Bioinformatics, Jnana Sahyadri, Kuvempu University, Shimoga 577451, Karnataka, India, Prabhakar B T| Molecular Biomedicine Laboratory, PG Dept. of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shimoga - 577203, Karnataka, India
Keywords
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