Evaluations of Drug-Drug Interactions in Hypertensive Patients in Secondary Care Hospital
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
1. Retrospective survey of potential Drug-Drug interactions. 2. To analyse the risk which it was associated with drug interaction in hypertensive patients. 3. To identify the drug that most commonly implanted in Drug-Drug interactions and to recognise the antihypertensive drug mostly interacting with other drug. Methodology The study was done at general medicine ward of secondary care hospital in Secunderabad for a period of 9 months for the detection of drug interactions in prescriptions containing anti hypertensive drugs which was prescribed. The study involves following steps Collection of prescription (schedule method). Recording of prescription details. Analyzing prescriptions and finding the individual drug interaction. Findings A total of 151 prescriptions were collected on the basis of inclusion (age, sex, other diseases like DM, etc) and exclusion (pregnant) criteria and analyzed for drug-drug interactions. It is shown that 20% (31) of prescriptions having drug-drug interactions in hypertensive patients. From these amlodipine is interacting with 8 drugs, furosemide with 5 drugs, atenolol with 6 drugs, enalapril with 5 drugs, ramipril with 3, digoxin with 2, nifedipine with 2, nebivolol with 2. From this study we concluded that amlodipine and digoxin, were commonly interacting with more no of drugs and nifedipine and nebivolol are least. Those 31 drug interactions case sheets were individually again studied and found that there were 26 different drug combinations causing interactions. Some drugs were interacting with more than one drug in the list. The severity of these 26 different interactions was founded that there were 4 major interaction and 15 moderate interactions. From this individualized study, amlodipine was found to be most interacting drug and combination which repeated mostly was amlodipine and atenolol, causing reduction in heart rate, cardiac contractility and hypotension. Conclusion It is concluded that the drug interaction cases constitutes 20% among the 151 hypertensive prescriptions. In future these drug interactions effectively overcome by Dose adjustment. Monitor blood pressure. Use combination with caution. Clinically monitoring the patient.
Authors and Affiliations
Sagar Pamu1, Tribhuvan Singh, S. Ravi3, S. V. Ranganayakulu2
Keywords
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- EP ID EP388812
- DOI 10.9790/3008-1202044550
- Views 83
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