Evalution of the Patients with Colon Polyps in Terms of Helicobacter pylori with Sydney Criteria
Journal Title: Türk Kolon ve Rektum Hastalıkları Dergisi - Year 2019, Vol 29, Issue 3
Abstract
Aim: Colorectal cancer (CRC) is one of the leading three cancers with high mortality. Colon polyps are precursors for CRC development. Helicobacter pylori is known to increase the risk of gastric cancer by intestinal metaplasia (IM) and glandular atrophy (GA), there are studies suggesting that it increases the risk of CRC by various mechanisms. Sydney criteria have been developed to provide a standardized approach to histopathological changes in gastric mucosa caused by H. pylori. The aim of this study was to evaluate H. pylori according to the Sydney criteria in patients with colon polyps and to contribute to the literature. Method: The study cohort included a control group (n=231) with normal colonoscopy findings and a patient group (n=600) who underwent upper gastrointestinal endoscopy and colonoscopy on the same day and had hyperplastic polyps, adenomatous polyps and malignant polyps. Age, gender, complications during endoscopy, number and localization of polyps, and histopathological results of gastric and colon biopsies were analyzed. The relationship between H. pylori, IM and GA and colon polyps were investigated with logistic regression model. Results: H. pylori was present in 609 (73.3%) of 831 patients. There was no statistically significant relationship between coexistence of H. pylori + IM and hyperplastic polyp and adenomatous polyp (p>0.05). It was found that IM did not increase the risk of CRC without H. pylori (p=0.15). There was a statistically significant relationship between CRC and H. pylori + IM (p=0.03). GA was detected in 70 patients (8.4%), and there was a statistically significant relationship between the presence of GA and CRC, regardless of the presence of H. pylori (p<0.05). Conclusion: The results of the study showed that the coexistence of H. pylori and IM did not increase the risk of colon hyperplastic polyps, adenomatous polyps, but increased the risk of malignant polyps. There was also a statistically significant relationship between colon malignant polyps in the presence of GA regardless of the presence of H. pylori. In the light of the data obtained in the study, patients with H. pylori and IM and patients with GA should be followed up more closely for malignant colon polyps.
Authors and Affiliations
Çağrı Akalın, Özlem Özdemir
Keywords
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- EP ID EP643340
- DOI 10.4274/tjcd.galenos.2019.79836
- Views 79
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