Event Monitoring in Patients Prescribed with Anti-tubercular Therapy
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 6
Abstract
Tuberculosis is a chronic, granulomatous infectious disease caused by Mycobacterium tuberculosis. Multi-drug resistance is a chronic problem associated with treatment of tuberculosis where a substantial proportion of tuberculosis cases reported in India are multi-drug resistant. Poor patient compliance plays a major role in development of resistance.The main objective of the study was to monitor the events associated with ATT in pulmonary and extra-pulmonary tuberculosis patients and to achieve better patient outcomes by regular monitoring. This was a prospective observational study which analysed patients diagnosed with pulmonary and extra-pulmonary kochs’, attending inpatient and out-patient departments as well as registered under the RNTCP at Dr. B.R Ambedkar Medical College and Hospital for a period of 1 year for any events associated with ATT. Routine investigations which are carried out by the patient at the treatment initiation and whenever required were monitored.A total of 175 patients were monitored in the study out of which majority were males. Most patients were category 1 patients. More than one-third of the patient population reported an adverse event.Most ADRs were related to the GI system, followed by Skin Allergy. Most of the events (72%) were patient reported during physician visit while 26% were reported on investigation. The study found that ADRs has led to medication incompliance which leads them to discontinue the medication for a short duration. Close monitoring of these events from the treatment initiation should be emphasized to prevent medication in adherence. It is suggested that the establishment of pharmacovigilance programs in DOTS centres is essential. Keywords:ATT, Anti-tubercular Therapy, Tuberculosis, Adverse Events.
Authors and Affiliations
Vaishnavi Prasannan, Dr. K. K Shyamala, Binai K Sankar, Saumya Sabu, Khalid P K, Legimol Sunny
Keywords
Related Articles
- EP ID EP377771
- DOI -
- Views 52
- Downloads 0
Effects of Cholinesterase Inhibitors on Experimental Model of Retrograde Amnesia
The Tacrine and Galantamine are cholinesterase inhibitors for treatment of Alzheimer’s disease. The pentylentetrazole model of retrograde amnesia is suitable for studying of learning and memory impairments. The aim of pr...
Formulation and Evaluation of Dispersible Tablet of Ornidazole
Abstract: This Present research with dispersible tablet can compromise the efficacy and safety of thetreatment to children’s and geriatric patients with masking the bitter taste of drug and developing its dispersible tab...
Gossypol: a potential promising anticancer agent
Despite the enormous amount of research and rapid developments seen during the past decades, cancer continues to be a killer and a major public health problem worldwide. Gossypol, a polyphenolic compound derived from cot...
Activity of anti-cancer protein kinase inhibitors against growth of different stages of Leishmania spp.
Current situation of Leishmaniasis calls for search of more effective drug. Multiplication of Leishmania resembles the development of mammalian tumor cells and both are regulated by the same mechanisms and having similar...
In-vitro Micropropagation and antimicrobial activity of Chrysanthemum indicum
Plants have been an important source of medicine for thousands of years. The World Health Organization estimates that up to 80% of people use plants which has traditional remedies such as herbs. Chrysanthemum indicum is...