Everolimus in clinical practice. Review of German non-interventional study of everolimus in metastatic renal cell cancer after failure of initial tyrosine kinase inhibitor therapy
Journal Title: OncoReview - Year 2013, Vol 3, Issue 3
Abstract
Everolimus is a standard for treatment of anti-vascular endothelial growth factor (VEGF)-refractory patients with metastatic renal cell carcinoma (mRCC). A German study documented mRCC patient treated everolimus from 79 sites. Results from German study were better then RECORD-1 study – the median time to progression was 7 months versus the median progression free survival was 4.9 months but results from non-interventional study should be treated with reserve. Tolerance of everolimus was good. Pneumonitis was reported as an AE for only 3% patient, in RECORD-1 study in 14%. Results from German study and strategy of sequential treatment were discussed (results from studies INORSECT, AXIS, RECORD-3).
Authors and Affiliations
Paweł Nurzyński, Andrzej Deptała
Keywords
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