Evidence Based Alzheimer’s Like Pathology in Normal Aging Brain
Journal Title: Scholars International Journal of Anatomy and Physiology - Year 2018, Vol 1, Issue 2
Abstract
Abstract:The evidence-based morphometric study was carried out to ascertain the Alzheimer’s like pathology in normal aging brain in Navi Mumbai, India.35 normal human cadaver brain specimens were acquired from MGM Medical College, Navi Mumbai, and (Alzheimer`s disease brains) NIMHANS, Bangalore, after meeting the ethical clearance from MGMIHS. Control group of Alzheimer’s disease was considered. A history based on CERAD criteria was used for informent scale. We divided the total brains into five groups; group I (20 to 39 years), group II (40 to 59 years), group III (60 to 79 years), group IV (>80 years) and a control-group V (Alzheimer`s brain specimen). We recorded gross features, cortical thickness and the ventricular dilatation in each brain. The chi - square test was applied for calculating cortical atrophy and ventricular dilatation of various age groups. One way ANOVA test was applied to the relation between different age groups using the SPSS19 software. In our study, the mean reduction in brain weight was evident from the 6th decade of life with minimum weight of 800gm (951.90±101.3gm). A substantial difference in the average weight of the brain in different age group was observed (p<. 001). Cortical atrophy and ventricular dilatation was evident of 20% in group II, 60% in group III and 100% in group IV (p<. 01). Keyword:Alzhimers disease, Aging, Atrophy, Degeneration, Dementia.
Authors and Affiliations
Pravin Raghunath Rathod, Monali D Sonawane, Aruna Mukherjee
Keywords
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